From neuronal activity to the actin cytoskeleton: a role for CaMKKs and betaPIX in spine morphogenesis.

Ciani L; Salinas PC

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From neuronal activity to the actin cytoskeleton: a role for CaMKKs and betaPIX in spine morphogenesis.

机译：从神经元活动到肌动蛋白细胞骨架：CaMKK和betaPIX在脊柱形态发生中的作用。

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Electrical activity plays a crucial role in neuronal circuit assembly. Activation of NMDA receptors induces the elevation of intracellular calcium, resulting in the modulation of calcium-calmodulin-dependent protein kinases (CaMKs). The CaMK pathway regulates synaptogenesis by driving the formation of dendritic spines. However, the molecular effectors downstream of this pathway have remained poorly defined. In this issue of Neuron, Saneyoshi et al. identify a new signaling complex containing CaMKK/CaMKI/betaPIX/Rac that regulates the morphogenesis of spines in an activity-dependent manner.

机译：电活动在神经元电路组装中起关键作用。 NMDA受体的激活诱导细胞内钙的升高，从而导致钙钙调蛋白依赖性蛋白激酶（CaMKs）的调节。 CaMK途径通过驱动树突棘的形成来调节突触形成。但是，该途径下游的分子效应器仍然不清楚。在本期《神经元》中，Saneyoshi等人。鉴定出一种新的信号复合物，其中包含CaMKK / CaMKI / betaPIX / Rac，该复合物以活性依赖的方式调节棘突的形态。

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《Neuron》 |2008年第1期|共2页
作者
Ciani L; Salinas PC;
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正文语种 eng
中图分类神经生理学;
关键词
Actins; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; 肌动蛋白类; 动物; 细胞周期蛋白质类; 细胞支架; 模型; 生物学; 形态发生; 神经元;

机译：Actins;Animals;Calcium-Calmodulin-Dependent Protein Kinases;Cell Cycle Proteins;肌动蛋白类;动物;细胞周期蛋白质类;细胞支架;模型;生物学;形态发生;神经元;

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1. From neuronal activity to the actin cytoskeleton: a role for CaMKKs and betaPIX in spine morphogenesis. [J] . Ciani L, Salinas PC Neuron . 2008,第1期

机译：从神经元活动到肌动蛋白细胞骨架：CaMKK和betaPIX在脊柱形态发生中的作用。
2. Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. [J] . Parisiadou L, Xie C, Cho HJ The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2009,第44期

机译：LRRK2对ezrin / radixin / moesin蛋白的磷酸化促进了神经元形态发生中肌动蛋白细胞骨架的重排。
3. The cytoskeleton and nucleus: the role of actin as a modulator of neuronal gene expression [J] . B. Knöll, H. Beck e-Neuroforum . 2011,第1期

机译：细胞骨架和细胞核：肌动蛋白作为神经元基因表达调节剂的作用
4. Study of the effect of a proteasome inhibitor on actin cytoskeleton remodeling in the nerve cells by fluorescence imaging [C] . Natalia S. Maximova, Vladimir I. Pershin, Natalia M. Tkachenko, Saratov Fall Meeting;SPIE Conference on Optical and Nano-Technologies for Biology and Medicine;International Symposium on Optics and Biophotonics . 2020

机译：荧光成像荧光成像对神经细胞肌蛋白细胞骨架重塑的蛋白酶体抑制剂的影响
5. Microtubule Plus-End Tracking Protein and Polymerase, XMAP215, Affects the Neuronal Microtubule and Actin Cytoskeletons to Control Axon Outgrowth and Guidance Mechanisms [D] . Cammarata, Garrett. 2020

机译：微管加端跟踪蛋白和聚合酶，XMAP215，影响神经元微管和肌动蛋白细胞骨骼，以控制轴突过多和引导机制
6. From neuronal activity to the actin cytoskeleton: a role for CaMKKs and ßPIX in spine morphogenesis [O] . Lorenza Ciani, Patricia C. Salinas -1

机译：从神经元活动到肌动蛋白细胞骨架：CaMKK和ßPIX在脊柱形态发生中的作用
7. From Neuronal Activity to the Actin Cytoskeleton: A Role for CaMKKs and βPIX in Spine Morphogenesis [O] . Ciani Lorenza, Salinas Patricia C. 2008

机译：从神经元活动到肌动蛋白细胞骨架：CaMKKs和βPIX在脊柱形态发生中的作用

From neuronal activity to the actin cytoskeleton: a role for CaMKKs and betaPIX in spine morphogenesis.

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