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首页> 外文期刊>Neuron >Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus.
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Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus.

机译：Wnt信号介导成年海马中的经验相关的突触数量和苔藓纤维连接的调节。

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摘要

We investigated how experience regulates the structure of a defined neuronal circuit in adult mice. Enriched environment (EE) produced a robust and reversible increase in hippocampal stratum lucidum synapse numbers, mossy fiber terminal (LMT) numbers, and spine plus synapse densities at LMTs, whereas a distinct mechanism depending on Rab3a promoted LMT volume growth. In parallel, EE increased postsynaptic CA3 pyramidal neuron Wnt7a/b levels. Inhibiting Wnt signaling through locally applied sFRP-1 suppressed the effects of EE on synapse numbers and further reduced synapse numbers in control mice. Wnt7 applied to CA3 mimicked the effects of EE on synapse and LMT numbers. CA3 Wnt7a/b levels were enhanced by excitatory activity and reduced by sFRP-1. Synapse numbers and Wnt7a/b levels peaked in mice aged 6-12 months; a decline in aged mice was reversed by EE. Therefore, behavioral experience specifically regulates adult global stratum lucidum synapse numbers and hippocampal network structure through Wnt signaling.
机译：我们调查了经验如何调节成年小鼠中定义的神经元回路的结构。丰富的环境（EE）使LMT处的海马透明层突触数量，苔藓纤维末端（LMT）数量和脊柱加突触密度强劲而可逆地增加，而依赖于Rab3a的独特机制促进了LMT量的增长。同时，EE增加了突触后CA3锥体神经元Wnt7a / b的水平。通过局部应用的sFRP-1抑制Wnt信号传导抑制了EE对突触数量的影响，并进一步降低了对照小鼠的突触数量。应用于CA3的Wnt7模仿了EE对突触和LMT数量的影响。 CA3 Wnt7a / b水平通过兴奋性活动而增加，而通过sFRP-1减少。在6-12个月大的小鼠中，突触数量和Wnt7a / b水平达到峰值。 EE逆转了衰老小鼠的下降。因此，行为经验特别通过Wnt信号调节成年的全局透明层突触数目和海马网络结构。

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