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首页> 外文期刊>New biotechnology >The lipidic extract of the seaweed Gracilariopsis longissima (Rhodophyta, Gracilariales): a potential resource for biotechnological purposes?
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The lipidic extract of the seaweed Gracilariopsis longissima (Rhodophyta, Gracilariales): a potential resource for biotechnological purposes?

机译：海藻Gracilariopsis longissima（Rhodophyta，Gracilariales）的脂质提取物：用于生物技术目的的潜在资源吗？

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In recent years seaweeds increasingly attracted interest in the search for new drugs and have been shown to be a primary source of bioactive natural products including antibiotics. In the present investigation the antimicrobial activity of Gracilariopsis longissima lipidic extract was assayed and its chemical characterization was carried out by means of advanced analytical techniques such as gaschromatography and multinuclear and multidimensional NMR spectroscopy. G. longissima lipidic extract showed an antibacterial activity against several Vibrio species. These results are interesting considering both the resistance against antibiotics developed by vibrios and the need to control fish and shellfish diseases due to vibriosis. Analysis of fatty acid methyl esters performed by gas-chromatography showed that palmitic acid methyl ester (16:0) was the predominant saturated fatty acid (42%), while, among monounsaturated fatty acids, oleic acid methyl ester (18:1) prevailed (8.5%). Because the palmitic acid represents the main component of fatty acids we hypothesized its involvement in the antibacterial activity observed. However, a pure sample of palmitic acid did not show an antibacterial activity. The fatty acid profile of G. longissima revealed also an interesting composition in polyunsaturated fatty acids and in particular the ratio of v-3 to v-6 fatty acids was >1 thus suggesting that this macroalga may be used as a natural source of v3. Moreover, the 1H NMR spectrum in CDCl_3 of algal lipid fraction shows the characteristic signals of saturated and unsaturated fatty acids as well as other metabolites. Interestingly, in the lipid extract the presence of polyhydroxybutyrate, a linear biodegradable and biocompatible polyester, was clearly identified by NMR spectroscopy. In conclusion, the lipidic extract of G. longissima on account of its antimicrobial activity, nutritional value and content in biodegradable and biocompatible polyester represents an interesting potential biotechnological resource.
机译：近年来，海藻对寻找新药的兴趣日益浓厚，已被证明是包括抗生素在内的生物活性天然产物的主要来源。在本研究中，测定了龙须草脂质提取物的抗菌活性，并通过先进的分析技术（如气相色谱法，多核和多维NMR光谱法）对其化学性质进行了表征。 G. longissima脂质提取物显示了对几种弧菌的抗菌活性。考虑到对弧菌产生的抗生素的抗药性以及由于弧菌病而需要控制鱼类和贝类疾病的考虑，这些结果很有趣。通过气相色谱分析脂肪酸甲酯表明，棕榈酸甲酯（16：0）是主要的饱和脂肪酸（42％），而在单不饱和脂肪酸中，油酸甲酯（18：1）占主导（8.5％）。因为棕榈酸代表脂肪酸的主要成分，所以我们假设它参与了观察到的抗菌活性。但是，纯棕榈酸样品没有显示抗菌活性。长牛发菌的脂肪酸谱还揭示了多不饱和脂肪酸中有趣的组成，特别是v-3与v-6脂肪酸的比率> 1，因此表明该大型藻类可用作v3的天然来源。此外，藻类脂质级分的CDCl_3中的1H NMR谱图显示了饱和和不饱和脂肪酸以及其他代谢物的特征信号。有趣的是，在脂质提取物中，通过NMR光谱法清楚地鉴定了聚羟基丁酸酯的存在，该聚羟基丁酸酯是线性的可生物降解和生物相容的聚酯。总之，由于其抗菌活性，营养价值以及可生物降解和生物相容性聚酯中的含量，G.longissima的脂质提取物代表了一种有趣的潜在生物技术资源。

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