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首页> 外文期刊>Neuropharmacology >An investigation of the expression mechanism of LTP of AMPA receptor-mediated synaptic transmission at hippocampal CA1 synapses using failures analysis and dendritic recordings.
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An investigation of the expression mechanism of LTP of AMPA receptor-mediated synaptic transmission at hippocampal CA1 synapses using failures analysis and dendritic recordings.

机译：使用故障分析和树突状记录研究AMPA受体介导的突触传递在海马CA1突触中LTP的表达机制。

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摘要

There is considerable controversy surrounding the mechanism of expression of long-term potentiation of AMPA receptor-mediated synaptic transmission in the CA1 region of the hippocampus, a process thought to be important for learning and memory in the mammalian CNS. We have re-examined the expression mechanism of this form of synaptic plasticity using whole-cell dendritic recordings, minimal stimulation to activate one or a few synapses, and failures analysis. Dendritic recordings provide improved resolution of small synaptic events, as compared to previous studies using somatic recordings, because there is less dendritic filtering of signals. We find that long-term potentiation (LTP) is associated with changes in the size of synaptic responses when they occur (potency) in all cells and this is accompanied by significant decreases in failure rate in approximately 60% of the experiments. This suggests that in some cells an increase in quantal amplitude is the sole expression mechanism for LTP and, in the cells where failure rate decreased, there is an additional mechanism causing a change in quantal content.
机译：关于海马CA1区AMPA受体介导的突触传递的长期增强表达机制的研究，存在很大争议，这一过程被认为对哺乳动物中枢神经系统的学习和记忆很重要。我们已经使用全细胞树突状记录，最小程度地激活一个或几个突触的刺激以及失败分析重新检查了这种形式的突触可塑性的表达机制。与以前使用体细胞记录的研究相比，树突状记录提供了更小的突触事件分辨率，因为信号的树突过滤较少。我们发现，长时程增强（LTP）与所有细胞中发生的突触反应大小变化（潜能）相关，并且伴随着大约60％的实验失败率显着降低。这表明在某些单元格中，振幅的增加是LTP的唯一表达机制，而在故障率降低的单元格中，还有另一种机制会导致数量含量的变化。

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