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首页> 外文期刊>Neurobiology of Aging: Experimental and Clinical Research >Pentyl-4-yn-valproic acid reverses age-associated memory impairment in the Wistar rat.
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Pentyl-4-yn-valproic acid reverses age-associated memory impairment in the Wistar rat.

机译：Pentyl-4-yn-丙戊酸可逆转Wistar大鼠的年龄相关记忆障碍。

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摘要

Pentyl-4-yn-valproic acid (VPA), a cognition-enhancing agent whose mode of action has been attributed to cell adhesion molecule-mediated neuritogenesis, has been shown to enhance hippocampus-dependent spatial learning. Here, we investigated its potential to reverse age-related memory impairment that relates mainly to declarative memory. Aged spatial learning deficits in the water maze paradigm were demonstrated by swim angle analysis, the angle between axes of start-to-platform and start-to-animal position, and latency to reach a submerged platform. Chronic pentyl-4-yn-VPA administration mediated a significant improvement in both search strategy and latency to find the submerged platform in aged animals. Pentyl-4-yn-VPA also facilitated task recall in aged animals as evidenced by increased time in the target quadrant during a probe trial 3 days following the final training session. The action of pentyl-4-yn-VPA on platform latency, search strategy and task recall suggests that this agent may have greatbenefit in the treatment of age-dependent cognitive decline.
机译：Pentyl-4-yn-丙戊酸（VPA）是一种认知增强剂，其作用方式可归因于细胞粘附分子介导的神经形成，可增强海马依赖性空间学习。在这里，我们研究了其逆转与陈述性记忆有关的与年龄有关的记忆障碍的潜力。通过游动角分析，开始到平台和开始到动物位置的轴之间的角度以及到达水下平台的潜伏期，证明了水迷宫范式中的老年空间学习缺陷。慢性戊基-4-yn-VPA的给药介导了寻找老年动物淹没平台的搜索策略和潜伏期的显着改善。 Pentyl-4-yn-VPA还促进了老年动物的任务召回，这一点可以通过在最后一次训练后3天进行的探针试验在目标象限中增加时间来证明。戊基-4-yn-VPA对平台潜伏期，搜索策略和任务回想的作用表明，该药物在治疗年龄依赖性认知功能减退方面可能具有巨大优势。

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