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首页> 外文期刊>Neuropsychobiology >Investigating the Effects of Estradiol or Estradiol/Progesterone Treatment on Mood, Depressive Symptoms, Menopausal Symptoms and Subjective Sleep Quality in Older Healthy Hysterectomized Women: A Questionnaire Study.
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Investigating the Effects of Estradiol or Estradiol/Progesterone Treatment on Mood, Depressive Symptoms, Menopausal Symptoms and Subjective Sleep Quality in Older Healthy Hysterectomized Women: A Questionnaire Study.

机译：研究雌二醇或雌二醇/孕酮治疗对老年健康的子宫切除手术女性的情绪，抑郁症状，更年期症状和主观睡眠质量的影响：一项问卷研究。

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Clinical studies have documented that estrogen treatment often ameliorates mood disturbances and depressive symptoms occurring during the menopausal transition. The relevance of gonadal hormones for mood and well-being in healthy older nondepressed women is less well understood. Fifty-one healthy hysterectomized women (mean age 64) participated in a placebo-controlled double-blind study on the effects of gonadal hormones on cognition. They received either estradiol (2 mg estradiol valerate), estradiol plus progesterone (100 mg micronized progesterone) or placebo. Mood, well being, menopausal symptoms, depressive symptoms and subjective sleep quality were measured at baseline and after 4 and 24 weeks of treatment using three questionnaires. Thirty-five women could be included into the final analysis. Strong increases in estradiol and progesterone levels occurred in response to the treatment. The two hormones, however, had no effects on mood, well-being, menopausal symptoms, sleep quality and depressive symptoms. The current small study suggests that older healthy nondepressed hysterectomized women do not react with positive or negative mood changes to estradiol or estradiol/progesterone treatment. Copyright (c) 2005 S. Karger AG, Basel.
机译：临床研究表明，雌激素治疗通常可以缓解绝经期过渡期患者的情绪障碍和抑郁症状。性腺激素与健康的老年非抑郁女性的情绪和福祉的相关性还鲜为人知。 51名健康的子宫切除术女性（平均年龄64岁）参加了一项关于性腺激素对认知的影响的安慰剂对照双盲研究。他们接受了雌二醇（2 mg戊酸雌二醇），雌二醇加孕酮（100 mg微粉化孕酮）或安慰剂。使用三份问卷在基线时以及治疗4周和24周后测量情绪，健康状况，更年期症状，抑郁症状和主观睡眠质量。可以将35名妇女纳入最终分析。响应治疗，雌二醇和孕酮水平显着增加。然而，这两种激素对情绪，幸福感，更年期症状，睡眠质量和抑郁症状没有影响。目前的一项小型研究表明，健康未抑郁的未切除子宫的老年妇女对雌二醇或雌二醇/孕激素治疗不会产生积极或消极的情绪变化。版权所有（c）2005 S.Karger AG，巴塞尔。

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