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首页> 外文期刊>Neuropsychologia >1Hz rTMS of the left posterior parietal cortex (PPC) modifies sensorimotor timing
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1Hz rTMS of the left posterior parietal cortex (PPC) modifies sensorimotor timing

机译:左后顶叶皮层(PPC)的1Hz rTMS改变感觉运动时机

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In order to investigate the relevance of the left posterior parietal cortex (PPC) for precise sensorimotor timing we applied 1. Hz repetitive transcranial magnetic stimulation (rTMS) over left PPC, right PPC and visual cortex of healthy participants for 10. min, respectively. The impact on sensorimotor timing of the right hand was assessed using a synchronization task that required subjects to synchronize their right index finger taps with respect to constant auditory, visual or auditory-visual pacing. Our results reveal reduced negative tap-to-pacer asynchronies following rTMS of the left PPC in all pacing conditions. This effect lasted for about 5. min after cessation of rTMS. Right PPC and visual cortex stimulation did not yield any significant behavioural effects. Since suppression of left PPC modified right-hand synchronization accuracy independent of the pacing signal's modality, the present data support the significance of left PPC for anticipatory motor control over a primary role in multisensory integration. The present data suggest that 1. Hz rTMS might interrupt a matching process of anticipated and real sensorimotor feedback within PPC. Alternatively, downregulation of left PPC activity may affect M1 excitability via functional connections leading to a delay in motor output and, thus, smaller tap-to-pacer asynchronies.
机译:为了研究左后顶叶皮层(PPC)与精确的感觉运动时机的相关性,我们分别对健康参与者的左PPC,右PPC和视皮层分别施加了10. Hz重复经颅磁刺激(rTMS),持续时间为10分钟。使用同步任务评估了对右手感觉运动时机的影响,该任务要求受试者针对持续的听觉,视觉或听觉-视觉起搏使他们的右手食指轻拍同步。我们的结果表明,在所有起搏条件下,左PPC的rTMS跟随负起搏对步头的异步性都会降低。 rTMS停止后,这种效果持续约5分钟。正确的PPC和视觉皮层刺激未产生任何明显的行为影响。由于抑制左PPC修改了右手同步精度,而与起搏信号的模态无关,因此本数据支持左PPC对于预期的运动控制的重要性,而这种控制是在多传感器集成中的主要作用。目前的数据表明1. Hz rTMS可能会中断PPC中预期的和实际的感觉运动反馈的匹配过程。或者,左PPC活动的下调可能会通过功能连接影响M1兴奋性,从而导致电机输出延迟,从而导致较小的Tap-to-Paper异步。

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