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首页> 外文期刊>Neuropsychologia >Recollection and familiarity in amnestic mild cognitive impairment: a global decline in recognition memory.
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Recollection and familiarity in amnestic mild cognitive impairment: a global decline in recognition memory.

机译：记忆轻度认知障碍的回忆和熟悉：认知记忆的整体下降。

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摘要

Despite memory failures being a central feature of amnestic mild cognitive impairment (a-MCI), there is limited research into the nature of the memory impairment associated with this condition. A further understanding could lead to refinement of criteria needed to qualify for this designation and aid in prediction of who will progress to development of clinical Alzheimer's disease. Dual process models posit that recognition memory is supported by the dissociable processes of recollection and familiarity. The present study sought to evaluate recognition memory in a-MCI in the framework of the dual process model. Patients with a-MCI and age- and education-matched controls were tested on three memory paradigms. Two paradigms were modifications of the process-dissociation procedure in which recollection required either memory of word-pair associations (associative) or the font color of words at study (featural). A final paradigm utilized the task-dissociation methodology comparing performance for item and visual spatial source memory. All three tasks revealed that familiarity was impaired to at least the same extent as recollection. As familiarity is thought to be spared in normal aging, its measurement may provide a relatively specific marker for the early pathological changes of Alzheimer's disease.
机译：尽管记忆障碍是轻度轻度认知障碍（a-MCI）的主要特征，但与这种情况相关的记忆障碍的性质的研究仍很有限。进一步的理解可能会导致符合该指定条件的标准的完善，并有助于预测谁将发展为临床阿尔茨海默氏病。双重过程模型假定识别记忆由可分离的回忆和熟悉过程支持。本研究试图在双重过程模型的框架内评估a-MCI中的识别记忆。对患有a-MCI以及年龄和文化程度相匹配的对照的患者进行了三种记忆范例的测试。两个范例是对过程解离过程的修改，其中回忆需要记忆单词对联想（联想）或所研究单词的字体颜色（自然）。最终范例利用任务分解方法比较了项目和视觉空间源内存的性能。所有这三项任务都表明，与回忆相比，熟悉程度至少受到了损害。由于人们认为在正常的衰老过程中不需熟悉，因此它的测量结果可能为阿尔茨海默氏病的早期病理变化提供相对特定的标记。

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