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首页> 外文期刊>Neuroreport >Postsynaptically different inhibitory postsynaptic currents in Cajal-Retzius cells in the developing neocortex.
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Postsynaptically different inhibitory postsynaptic currents in Cajal-Retzius cells in the developing neocortex.

机译：在发展中的新皮层中的Cajal-Retzius细胞中突触后不同的抑制性突触后电流。

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摘要

Fast and slowly rising inhibitory postsynaptic currents (IPSCs, IPSCF and IPSCS) in neocortical Cajal-Retzius cells are observed. In this study, zolpidem, a benzodiazepine agonist that specifically modulates gamma-aminobutyric acid type A receptors (GABAARs) containing gamma2 subunit, was used to characterize GABAARs mediating IPSCF and IPSCS. One-hundred-nanomolar zolpidem prolonged IPSCS, increased evoked IPSCS (eIPSCS) amplitude, and decreased paired-pulse ratio (PPR) of eIPSCS. Two micromolar zolpidem prolonged both IPSCF and IPSCS, increased miniature IPSCF and eIPSCF amplitudes, increased eIPSCS amplitude but not miniature IPSCS amplitude, decreased PPR of eIPSCS, but failed to affect PPR of eIPSCF. We conclude that IPSCF are mediated by alpha2/3-containing GABAARs, which are not saturated by synaptic GABA release, whereas IPSCS are mediated by alpha1-containing and alpha2/3-containing GABAARs, which are saturated by quantal GABA release.
机译：在新皮层的Cajal-Retzius细胞中观察到快速和缓慢上升的抑制性突触后电流（IPSC，IPSCF和IPSCS）。在这项研究中，唑吡坦是一种苯二氮卓激动剂，可以特异性地调节包含gamma2亚基的Gamma-氨基丁酸A型受体（GABAARs），用于表征介导IPSCF和IPSCS的GABAAR。 100纳摩尔唑吡坦延长IPSCS，诱发IPSCS（eIPSCS）幅度增加，并降低eIPSCS的成对脉冲比率（PPR）。两个微摩尔唑吡坦延长了IPSCF和IPSCS的时间，增加了微型IPSCF和eIPSCF的振幅，增加了eIPSCS振幅，但没有使微型IPSCS振幅增加，降低了eIPSCS的PPR，但未能影响eIPSCF的PPR。我们得出结论，IPSCF由不被突触GABA释放饱和的含alpha2 / 3的GABAARs介导，而IPSCS由被定量GABA释放饱和的含alpha1和含α2/ 3的GABAARs介导。

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