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首页> 外文期刊>Neuropsychologia >Associative recognition in mild cognitive impairment: Relationship to hippocampal volume and apolipoprotein E
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Associative recognition in mild cognitive impairment: Relationship to hippocampal volume and apolipoprotein E

机译：轻度认知障碍中的联想识别：与海马体积和载脂蛋白E的关系

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摘要

Associative memory involves remembering relations between items of information and is critically dependent on the hippocampus, a brain structure that shows early changes in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease. We examined associative and item memory in aMCI with a focus on the role of medial-temporal lobe regions and genetic risk for Alzheimer's disease. Twenty-four individuals with aMCI and 21 demographically matched healthy older adults underwent associative recognition testing, structural brain imaging, and apolipoprotein E (ApoE) genotyping. A significant interaction between group and recognition type indicated poorer associative recognition than item recognition across tasks in the aMCI group relative to controls. Within the aMCI group, associative but not item recognition showed sizable and significant correlations with hippocampal volume (but not with other medial temporal-lobe structures) and with number of ApoE ε4 alleles. Correlations were smaller and generally not significant in the control group. Our findings replicate and extend previous studies by showing an associative recognition impairment in aMCI that is not accounted for by an item recognition deficit, is related to structural integrity of the hippocampus, and increases with genetic risk for Alzheimer's disease.
机译：联想记忆涉及记忆信息项之间的关系，并严重依赖于海马体，海马体的大脑结构显示出轻度轻度认知障碍（aMCI）和阿尔茨海默氏病的早期变化。我们检查了aMCI中的联想和项目记忆，重点是内侧颞叶区域的作用和阿尔茨海默氏病的遗传风险。 24名患有aMCI的个体和21位人口统计学匹配的健康老年人接受了相关识别测试，脑结构成像和载脂蛋白E（ApoE）基因分型。组和识别类型之间的显着相互作用表明，与aMCI组中的各个任务相比，相对于控件而言，关联识别要差。在aMCI组中，联想但与项目识别无关，与海马体积（但与其他内侧颞叶结构无关）与ApoEε4等位基因数量具有显着且显着的相关性。对照组的相关性较小，通常不显着。我们的发现通过显示aMCI中的关联性识别障碍，而不是由项目识别缺陷来解释，与海马的结构完整性有关，并且随着阿尔茨海默氏病的遗传风险而增加，从而重复并扩展了先前的研究。

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