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首页> 外文期刊>Neuropsychologia >The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people
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The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people

机译：精神分裂症的神经生物学：额叶纹状体预测错误信号与健康人的妄想样信念相关

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Healthy people sometimes report experiences and beliefs that are strikingly similar to the symptoms of psychosis in their bizarreness and the apparent lack of evidence supporting them. An important question is whether this represents merely a superficial resemblance or whether there is a genuine and deep similarity indicating, as some have suggested, a continuum between odd but healthy beliefs and the symptoms of psychotic illness. We sought to shed light on this question by determining whether the neural marker for prediction error - previously shown to be altered in early psychosis - is comparably altered in healthy individuals reporting schizotypal experiences and beliefs. We showed that non-clinical schizotypal experiences were significantly correlated with aberrant frontal and striatal prediction error signal. This correlation related to the distress associated with the beliefs. Given our previous observations that patients with first episode psychosis show altered neural responses to prediction error and that this alteration, in turn, relates to the severity of their delusional ideation, our results provide novel evidence in support of the view that schizotypy relates to psychosis at more than just a superficial descriptive level. However, the picture is a complex one in which the experiences, though associated with altered striatal responding, may provoke distress but may nonetheless be explained away, while an additional alteration in frontal cortical responding may allow the beliefs to become more delusion-like: intrusive and distressing.
机译：健康的人有时会报告自己的经历和信念与精神病的症状极为相似，其怪异之处以及明显缺乏支持他们的证据。一个重要的问题是，这是否仅表示表面上的相似之处，还是像某些人所暗示的那样，是否存在真正而深刻的相似性，表明奇特但健康的信念与精神病症状之间存在着连续性。我们试图通过确定预测精神错乱的神经标志物（先前已证明在早期精神病中已发生改变）是否在报告了精神分裂型经历和信念的健康个体中发生了可比的变化来阐明这一问题。我们显示非临床的精神分裂型经验与异常的额叶和纹状体预测误差信号显着相关。这种关联与与信念相关的困扰有关。鉴于我们先前的观察发现，患有首发性精神病的患者对预测错误表现出神经反应的改变，而这种改变又与他们妄想的严重程度有关，我们的结果提供了新的证据来支持精神分裂症与精神错乱有关。不只是表面上的描述水平。然而，这是一幅复杂的图景，其中的经历虽然与纹状体反应改变有关，但可能会激起痛苦，但仍可以解释，而额叶皮层反应的其他改变可能会使信念变得更像妄想：侵入式和痛苦。

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