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首页> 外文期刊>Neuropsychologia >Unisensory processing and multisensory integration in schizophrenia: a high-density electrical mapping study.
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Unisensory processing and multisensory integration in schizophrenia: a high-density electrical mapping study.

机译：精神分裂症的单感觉处理和多感觉整合：高密度电图研究。

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In real-world settings, information from multiple sensory modalities is combined to form a complete, behaviorally salient percept - a process known as multisensory integration. While deficits in auditory and visual processing are often observed in schizophrenia, little is known about how multisensory integration is affected by the disorder. The present study examined auditory, visual, and combined audio-visual processing in schizophrenia patients using high-density electrical mapping. An ecologically relevant task was used to compare unisensory and multisensory evoked potentials from schizophrenia patients to potentials from healthy normal volunteers. Analysis of unisensory responses revealed a large decrease in the N100 component of the auditory-evoked potential, as well as early differences in the visual-evoked components in the schizophrenia group. Differences in early evoked responses to multisensory stimuli were also detected. Multisensory facilitation was assessed by comparing the sum of auditory and visual evoked responses to the audio-visual evoked response. Schizophrenia patients showed a significantly greater absolute magnitude response to audio-visual stimuli than to summed unisensory stimuli when compared to healthy volunteers, indicating significantly greater multisensory facilitation in the patient group. Behavioral responses also indicated increased facilitation from multisensory stimuli. The results represent the first report of increased multisensory facilitation in schizophrenia and suggest that, although unisensory deficits are present, compensatory mechanisms may exist under certain conditions that permit improved multisensory integration in individuals afflicted with the disorder.
机译：在现实世界中，来自多种感觉模态的信息被组合在一起，形成一个完整的，行为上显着的感知力-这一过程称为多感觉整合。虽然在精神分裂症中经常观察到听觉和视觉处理的缺陷，但对这种疾病如何影响多感觉整合的了解却很少。本研究使用高密度电图检查了精神分裂症患者的听觉，视觉和组合视听处理。使用与生态相关的任务比较精神分裂症患者的单感觉和多感觉诱发电位与健康正常志愿者的电位。对单感觉反应的分析显示，精神分裂症组的听觉诱发电位的N100成分显着降低，以及视觉诱发成分的早期差异。还检测到对多种感觉刺激的早期诱发反应的差异。通过比较听觉和视觉诱发反应的总和与视听诱发反应的总和来评估多感觉促进。与健康志愿者相比，精神分裂症患者对视听刺激的绝对幅度响应明显大于对单感觉总和的响应，表明患者组中的多感觉促进作用明显增强。行为反应也表明来自多感觉刺激的促进作用增加。该结果代表了精神分裂症中多感官促进的增加的第一份报告，并且表明，尽管存在单感官缺陷，但在某些情况下可能存在代偿机制，从而在患病的个体中改善了多感官整合。

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