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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Nucleus reuniens thalami innervates gamma aminobutyric acid positive cells in hippocampal field CA1 of the rat.
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Nucleus reuniens thalami innervates gamma aminobutyric acid positive cells in hippocampal field CA1 of the rat.

机译：reuniens thalami神经支配大鼠海马区CA1中的γ-氨基丁酸阳性细胞。

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摘要

The aim of the present study was to investigate whether the nucleus reuniens thalami (RE) innervates inhibitory cells in hippocampal field CA1. Therefore, we examined the RE-CA1 input at the ultrastructural level. RE axons were anterogradely labeled with biotin-conjugated dextran amine (BDA), in combination with pre-embedding gamma aminobutyric acid (GABA)-immunolabeling of neurons in CA1. We observed that part of the BDA-labeled axons formed asymmetrical (i.e. excitatory) synapses on GABA-positive dendrites. Based on these data, which are in line with our previously published electrophysiological observations (Dolleman-Van der Weel, M.J., Lopes da Silva, F.H. and Witter, M.P., Nucleus reuniens thalami modulates activity in hippocampal field CA1 through excitatory and inhibitory mechanisms. J. Neurosci., 17 (1997) 5640-5650), we propose that RE-CA1 input partially influences hippocampal transmission through activation of local inhibitory interneurons.
机译：本研究的目的是调查海藻核（RE）是否神经支配海马区CA1中的抑制性细胞。因此，我们在超结构水平上检查了RE-CA1输入。 RE轴突被生物素偶联的右旋糖酐胺（BDA）与CA1中神经元的预嵌入γ-氨基丁酸（GABA）免疫标记结合进行顺行标记。我们观察到部分BDA标记的轴突在GABA阳性树突上形成不对称（即兴奋性）突触。基于这些数据，与我们先前发表的电生理学观察结果一致（Dolleman-Van der Weel，MJ，Lopes da Silva，FH和Witter，MP，Neuleus reuniens thalami通过兴奋性和抑制性机制调节海马CA1区的活性。 （Neurosci。，17（1997）5640-5650），我们提出RE-CA1输入通过局部抑制性中间神经元的活化部分影响海马传播。

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