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首页> 外文期刊>Materials science & engineering, C. Materials for Biogical applications >Degradability of injectable calcium sulfate/mineralized collagen-based bone repair material and its effect on bone tissue regeneration
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Degradability of injectable calcium sulfate/mineralized collagen-based bone repair material and its effect on bone tissue regeneration

机译：可注射硫酸钙/矿化胶原基骨修复材料的降解性及其对骨组织再生的影响

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摘要

The nHAC/CSH composite is an injectable bone repair material with controllable injectability and self-setting properties prepared by introducing calcium sulfate hemihydrate (CSH) into mineralized collagen (nHAC). When mixed with water, the nHAC/CSH composites can be transformed into mineralized collagen/calcium sulfate dihydrate (nHAC/CSD) composites. The nHAC/CSD composites have good biocompatibility and osteogenic capability. Considering that the degradation behavior of bone repair material is another important factor for its clinical applications, the degradability of nHAC/CSD composites was studied. The results showed that the degradation ratio of the nHAC/CSD composites with lower nHAC content increased with the L/S ratio increase of injectable materials, but the variety of L/S ratio had no significant effect on the degradation ratio of the nHAC/CSD composites with higher nHAC content Increasing nHAC content in the composites could slow down the degradation of nHAC/CSD composite. Setting accelerator had no significant effect on the degradability of nHAC/CSD composites. In vivo histological analysis suggests that the degradation rate of materials can match the growth rate of new mandibular bone tissues in the implanted site of rabbit. The regulable degradability of materials resulting from the special prescriptions of injectable nHAC/CSH composites will further improve the workability of nHAC/CSD composites. (C) 2014 Elsevier B.V. All rights reserved.
机译：nHAC / CSH复合材料是通过将硫酸钙半水合物（CSH）引入矿化胶原蛋白（nHAC）中而制备的具有可控制的可注射性和自固化特性的可注射骨修复材料。与水混合时，nHAC / CSH复合材料可以转变为矿化的胶原蛋白/二水合硫酸钙（nHAC / CSD）复合材料。 nHAC / CSD复合材料具有良好的生物相容性和成骨能力。考虑到骨修复材料的降解行为是其临床应用的另一个重要因素，因此研究了nHAC / CSD复合材料的降解性。结果表明，nHAC含量较低的nHAC / CSD复合材料的降解率随注射材料的L / S比的增加而增加，但L / S比的变化对nHAC / CSD的降解率无明显影响。 nHAC含量较高的复合材料增加nHAC含量的复合材料可以减慢nHAC / CSD复合材料的降解。固化促进剂对nHAC / CSD复合材料的降解性没有明显影响。体内组织学分析表明，材料的降解速率可以与兔植入部位新的下颌骨组织的生长速率相匹配。由可注射nHAC / CSH复合材料的特殊处方产生的可调节材料降解性将进一步提高nHAC / CSD复合材料的可加工性。 （C）2014 Elsevier B.V.保留所有权利。

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