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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >Separation of A- versus C-nociceptive inputs into spinal-brainstem circuits.
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Separation of A- versus C-nociceptive inputs into spinal-brainstem circuits.

机译：将A感受伤害和C感受伤害的输入分离到脊椎脑干电路中。

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This study was designed to determine the organization of nociceptive inputs with different behavioral significance into spinal-brainstem circuits in the rat. Induction of Fos protein was used to localize spinal dorsal horn and hypothalamic neurons activated by noxious heating of the hind paw dorsum at rates known to preferentially activate C- or A-heat nociceptors. This was combined with retrograde transport of cholera toxin subunit B from the dorsolateral/lateral- (DL/L-) or the ventrolateral- (VL-) periaqueductal gray (PAG) in order to map the organization of A- and C-fiber input to spinal-brainstem circuits. The majority of dorsal horn heat-activated neurons were located in laminae I and II. A significantly larger proportion of C-fiber-activated neurons projected to the VL-PAG (P<0.05) compared with its DL/L-sector. In contrast, there was no columnar separation in the projections of A-fiber-activated neurons. However, a significantly greater proportion of A-fiber-activated neurons (P<0.05) were retrogradely labeled from the DL/L-PAG, when compared with C-fiber-activated neurons. A large proportion (25-50%) of A- and C-fiber-activated neurons in the lateral spinal nucleus projected to the PAG. A-fiber-activated neurons were found throughout the rostral hypothalamus but those projecting to the PAG were focused in the lateral area of the anterior hypothalamus (LAAH), from where approximately 20% projected to the VL-PAG, which was significantly more than to the DL/L PAG (P<0.05). We hypothesize that the organization of A- versus C-fiber inputs to the PAG enables the coordination of coping strategies appropriate to meet the demands imposed by these different noxious stimuli. Hypothalamic-PAG projections activated by A-fiber inputs did not reflect this level of organization and we suggest that this may relate to their role in thermoregulation as opposed to autonomic responses to particular nociceptive inputs.
机译：本研究旨在确定具有不同行为意义的伤害性输入在大鼠脊髓-脑干回路中的组织。 Fos蛋白的诱导被用于定位由后爪背的有毒加热以已知优先激活C或A热伤害感受器的速率激活的脊髓背角和下丘脑神经元。这与从背外侧/外侧-（DL / L-）或腹外侧-（VL-）导水管周围灰色（PAG）的霍乱毒素亚基B的逆向转运相结合，以绘制A纤维和C纤维输入的组织脊柱-脑干回路。大部分背角热激活神经元位于I和II层。与DL / L区相比，C纤维激活的神经元投射到VL-PAG的比例要大得多（P <0.05）。相反，在A纤维激活的神经元的投影中没有柱状分离。然而，与C纤维激活的神经元相比，从DL / L-PAG逆行标记的A纤维激活的神经元的比例更大（P <0.05）。脊柱外侧核中大部分（25-50％）的A和C纤维激活神经元投射到PAG。在整个下丘脑下丘脑中都发现了A纤维激活的神经元，但投射到PAG的神经元则集中在下丘脑前部（LAAH）的外侧区域，从那里大约有20％投射到VL-PAG，这远远超过了DL / L PAG（P <0.05）。我们假设，PAG的A纤维与C纤维输入的组织可以协调应对策略，以适应这些不同的有害刺激所施加的要求。由A纤维输入激活的下丘脑PAG预测并不能反映这种组织水平，我们建议这可能与其在温度调节中的作用有关，而不是对特定伤害感受输入的自主反应。

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