Study of Tissue-Specific CpG Methylation of DNA in Extended Genomic Loci

T.L.Azhikina; E.D.Sverdlov

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Study of Tissue-Specific CpG Methylation of DNA in Extended Genomic Loci

机译：扩展基因组位点中DNA的组织特异性CpG甲基化研究

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Modern approaches for studies on genome functioning include investigation of its epigenetic regulation.Methylation of cytosines in CpG dinucleotides is an inherited epigenetic modification that is responsible for both functional activity of certain genomic loci and total chromosomal stability.This review describes the main approaches for studies on DNA methylation.Under consideration are site-specific approaches based on bisulfite sequencing and methyl-sensitive PCR,whole-genome approaches aimed at searching for new methylation hot spots,and also mapping of unmethylated CpG sites in extended genomic loci.

机译：研究基因组功能的现代方法包括对其表观遗传调控的研究.CpG二核苷酸中胞嘧啶的甲基化是一种遗传的表观遗传修饰，负责某些基因组位点的功能活性和总染色体稳定性。 DNA甲基化。正在考虑的是基于亚硫酸氢盐测序和甲基敏感PCR的位点特异性方法，旨在寻找新的甲基化热点的全基因组方法，以及在扩展基因组位点中未甲基化CpG位点的作图。

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《Biochemistry》 |2005年第5期|共8页
作者
T.L.Azhikina; E.D.Sverdlov;
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正文语种 eng
中图分类生物化学;
关键词
DNA methylation analysis; bisulfite sequencing; methyl-sensitive PCR(MS-PCR); whole-genome approaches; Non-methylated Genomic Sites Coincidence Cloning(NGSCC);

机译：DNA甲基化分析;亚硫酸氢盐测序;甲基敏感的PCR（MS-PCR）;全基因组方法;非甲基化的基因组位点重合克隆（NGSCC）;

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专利

1. Study of Tissue-Specific CpG Methylation of DNA in Extended Genomic Loci [J] . T.L.Azhikina, E.D.Sverdlov Biochemistry . 2005,第5期

机译：扩展基因组位点中DNA的组织特异性CpG甲基化研究
2. Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists [J] . David Mossman, Kyu-Tae Kim, Rodney J Scott BMC Cancer . 2010,第1期

机译：大肠癌细胞中5-氮杂-2'-脱氧胞苷的脱甲基作用靶向基因组DNA，而启动子CpG岛甲基化持续存在
3. Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging [J] . Michelle W Chu, Kimberly D Siegmund, Carrie L Eckstam, BMC Medical Genetics . 2007,第1期

机译：非有丝分裂成年组织中三个富含CpG的基因组位点缺乏甲基化的增加
4. A comparative study for characterisation and prediction of tissue-specific DNA methylation of CpG islands in chromosomes 6, 20 and 22 [C] . Ali Isse, Seker Huseyin 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2010

机译：比较研究表征和预测染色体6、20和22中CpG岛的组织特异性DNA甲基化
5. The Study of Tissue-Specific DNA Methylation as a Method for the Epigenetic Discrimination of Forensic Samples [D] . Antunes, Joana Alexandra Pereira 2018

机译：组织特异性DNA甲基化作为法医样品表观遗传鉴别方法的研究
6. A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci [O] . Robert Illingworth, Alastair Kerr, Dina DeSousa, 2008

机译：一种新型的CpG岛集确定发育基因位点的组织特异性甲基化。
7. A novel CpG island set identifies tissue-specific methylation at developmental gene loci. [O] . Robert Illingworth, Alastair Kerr, Dina Desousa, 2008

机译：一种新的CpG岛组识别发育基因座的组织特异性甲基化。

Study of Tissue-Specific CpG Methylation of DNA in Extended Genomic Loci

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