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首页> 外文期刊>Neurosurgery >Effects of methylprednisolone on axonal depression induced by hypoxia, gamma-aminobutyric acid, and (+/-)-8-hydroxy-dipropylaminotetralin hydrobromide.
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Effects of methylprednisolone on axonal depression induced by hypoxia, gamma-aminobutyric acid, and (+/-)-8-hydroxy-dipropylaminotetralin hydrobromide.

机译：甲泼尼龙对缺氧，γ-氨基丁酸和（+/-）-8-羟基-二丙基氨基四氢呋喃氢溴酸盐引起的轴突抑制的影响。

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OBJECTIVE: We sought to confirm the effects of methylprednisolone (MP) on axonal depression induced by hypoxia, gamma-aminobutyric acid (GABA), and (+/-)-8-hydroxy-dipropylaminotetralin hydrobromide (8-OH-DPAT). METHODS: Compound action potentials were recorded to assess the effects of MP in neonatal rat spinal cord axons. Longitudinally hemisected spinal cords were superfused for 120 minutes in Ringer's solution saturated with 95% N2 and 5% CO2. The effect of MP on GABA- and 8-OH-DPAT-induced axonal depression was analyzed with oxygenated isolated dorsal columns. RESULTS: Hypoxia (120 min) significantly reduced the response amplitudes in hemicord preparations. MP (30 micromol/L) prevented hypoxia-induced depression of action potential amplitudes. In oxygenated dorsal column preparations, GABA (50 micromol/L) significantly reduced action potential amplitudes. At 10, 30, and 100 micromol/L, MP had no effect on axonal excitability and GABA-induced axonal depression. 8-OH-DPAT (100 micromol/L) significantly reduced the action potential amplitude. MP (10, 30, 50, and 100 micromol/L) reduced 8-OH-DPAT-induced amplitude depression in a dose-dependent manner. CONCLUSION: At the higher concentrations, MP protected spinal cord axons against hypoxia-induced excitability loss. It had an effect on serotonin 1A-induced axonal depression but not on GABA-induced depression.
机译：目的：我们试图确认甲泼尼龙（MP）对缺氧，γ-氨基丁酸（GABA）和（+/-）-8-羟基-二丙基氨基四氢溴酸氢溴酸盐（8-OH-DPAT）引起的轴突抑制的作用。方法：记录复合动作电位以评估MP在新生大鼠脊髓轴突中的作用。将经纵向切割的脊髓在含95％N2和5％CO2的林格氏溶液中融合120分钟。用含氧的隔离背柱分析了MP对GABA和8-OH-DPAT诱导的轴突抑制的影响。结果：缺氧（120分钟）显着降低了半线制剂的反应幅度。 MP（30 micromol / L）防止了低氧引起的动作电位振幅下降。在氧化背柱制剂中，GABA（50 micromol / L）显着降低了动作电位振幅。在10、30和100 micromol / L下，MP对轴突兴奋性和GABA引起的轴突抑制没有影响。 8-OH-DPAT（100 micromol / L）显着降低了动作电位振幅。 MP（10、30、50和100 micromol / L）以剂量依赖性方式减少了8-OH-DPAT引起的振幅下降。结论：在较高的浓度下，MP保护脊髓轴突免受缺氧引起的兴奋性丧失。它对5-羟色胺1A引起的轴突抑制作用有效，但对GABA诱导的抑制作用无效。

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