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首页> 外文期刊>Neurosurgery >High-resolution magnetic resonance imaging is a noninvasive method of observing injury and recovery in the peripheral nervous system.
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High-resolution magnetic resonance imaging is a noninvasive method of observing injury and recovery in the peripheral nervous system.

机译：高分辨率磁共振成像是观察周围神经系统损伤和恢复的一种非侵入性方法。

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OBJECTIVE: Noninvasive observation of degenerating and regenerating peripheral nerves could improve the diagnosis and treatment of nerve injuries. We constructed a novel phased-array radiofrequency coil to permit magnetic resonance imaging (MRI) observation of the sciatic nerve and its target muscles in rats after injury. METHODS: Adult male Lewis rats underwent either crushing (n = 18) or cutting and capping (n = 17) of their right sciatic nerves and then underwent serial MRI. Serial gait track analysis was performed to assess behavioral recovery. Animals from both groups were killed at several time points for histological evaluation of the nerves, with axon counting. RESULTS: Crushed sciatic nerves demonstrated increased T2-weighted signals, followed by signal normalization as axonal regeneration and behavioral recovery occurred. Cut sciatic nerves prevented from regenerating displayed a prolonged phase of increased signal intensity. Acutely denervated muscles exhibited hyperintense T2-weighted signals, which normalized with reinnervation and behavioral recovery. Chronically denervated muscles demonstrated persistently increased T2-weighted signals and atrophy. CONCLUSION: In this study, we demonstrated the ability of MRI to noninvasively monitor injury and recovery in the peripheral nervous system, by demonstrating changes in nerve and muscle that correlated with histological and behavioral evidence of axonal degeneration and regeneration. This study demonstrates the potential of MRI to distinguish traumatic peripheral nerve injuries that recover through axonal regeneration (i.e., axonotmetic grade) from those that do not and therefore require surgical repair (i.e., neurotmetic grade). This diagnostic modality could improve treatment by providing earlier and more accurate diagnoses of nerve damage, as well as reducing the need for exploratory surgery.
机译：目的：无创观察周围神经退化和再生可以改善神经损伤的诊断和治疗。我们构建了一种新型相控阵射频线圈，以允许大鼠受伤后坐骨神经及其靶肌的磁共振成像（MRI）观察。方法：对成年雄性Lewis大鼠进行右坐骨神经压迫（n = 18）或切开并加帽（n = 17），然后进行系列MRI。进行连续步态跟踪分析以评估行为恢复。两组动物均在几个时间点处死，以轴突计数对神经进行组织学评估。结果：坐骨神经碎裂显示T2加权信号增加，随后随着轴突再生和行为恢复发生信号正常化。切断的坐骨神经无法再生，显示出信号强度增加的延长阶段。急性神经支配的肌肉表现出高强度的T2加权信号，并随着神经支配和行为恢复而恢复正常。慢性神经支配的肌肉表现出持续增加的T2加权信号和萎缩。结论：在这项研究中，我们通过证明神经和肌肉的变化与轴突变性和再生的组织学和行为学证据相关，证明了MRI具有无创监测外周神经系统损伤和恢复的能力。这项研究表明MRI可以区分通过轴突再生（即轴突等级）恢复的创伤性周围神经损伤与不需要手术修复的创伤性周围神经损伤（即，神经疗法等级）。通过提供更早，更准确的神经损伤诊断以及减少探索性手术的需要，这种诊断方式可以改善治疗效果。

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