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首页> 外文期刊>Biochemistry >Use of the Flux Model of Amino Acid Metabolism of Escherichia coli
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Use of the Flux Model of Amino Acid Metabolism of Escherichia coli

机译：大肠杆菌氨基酸代谢通量模型的应用

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摘要

A program implementing a flux model of Escherichia coli metabolism was used to analyze the effects of the addition of amino acids (tryptophan,tyrosine,phenylalanine,leucine,isoleucine,valine,histidine,lysine,threonine,cysteine,methionine,arginine,proline) to minimal medium or media lacking nitrogen,carbon,or both.The overall response of the metabolic system to the addition of various amino acids to the minimal medium is similar.Glycolysis and the synthesis of pyruvate with its subsequent degradation to acetate via acetyl-CoA become more efficient,whereas the fluxes through the pentose phosphate pathway and the TCA cycle decrease.If amino acids are used as the sole source of carbon,nitrogen,or both,the changes in the flux distribution are determined mainly by the carbon limitation.The phosphoenolpyruvate to glucoses-phosphate flux increases; the flux through the pentose phosphate path is directed towards ribulose-5-phosphate.Other changes are determined by the compounds that are the primary products of catabolism of the added amino acid.
机译：使用实施大肠杆菌代谢通量模型的程序来分析添加氨基酸（色氨酸，酪氨酸，苯丙氨酸，亮氨酸，异亮氨酸，缬氨酸，组氨酸，赖氨酸，苏氨酸，半胱氨酸，蛋氨酸，精氨酸，脯氨酸）的效果。最低限度的培养基或缺乏氮，碳或两者兼有的培养基。代谢系统对向最低限度培养基中添加各种氨基酸的总体反应是相似的。糖酵解和丙酮酸的合成及其随后通过乙酰辅酶A降解为乙酸盐如果使用氨基酸作为碳，氮或两者的唯一来源，则通量分布的变化主要取决于碳的限制。磷酸烯醇式丙酮酸葡萄糖-磷酸盐通量增加;通过磷酸戊糖途径的通量直接流向5核糖核糖。其他变化由化合物决定，这些化合物是添加的氨基酸分解代谢的主要产物。

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