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首页> 外文期刊>Neurosurgical focus >Volumetric analysis of syringomyelia following hindbrain decompression for Chiari malformation type I: Syringomyelia resolution follows exponential kinetics
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Volumetric analysis of syringomyelia following hindbrain decompression for Chiari malformation type I: Syringomyelia resolution follows exponential kinetics

机译：I型Chiari畸形后肢减压后脊髓空洞症的体积分析：脊髓空洞症的解决遵循指数动力学

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Object. Resolution of syringomyelia is common following hindbrain decompression for Chiari malformation, yet little is known about the kinetics governing this process. The authors sought to establish the volumetric rate of syringomyelia resolution. Methods. A retrospective cohort of patients undergoing hindbrain decompression for a Chiari malformation Type I with preoperative cervical or thoracic syringomyelia was identified. Patients were included in the study if they had at least 3 neuroimaging studies that detailed the entirety of their preoperative syringomyelia over a minimum of 6 months postoperatively. The authors reconstructed the MR images in 3 dimensions and calculated the volume of the syringomyelia. They plotted the syringomyelia volume over time and constructed regression models using the method of least squares. The Akaike information criterion and Bayesian information criterion were used to calculate the relative goodness of fit. The coefficients of determination R2 (unadjusted and adjusted) were calculated to describe the proportion of variability in each individual data set accounted for by the statistical model. Results. Two patients were identified as meeting inclusion criteria. Plots of the least-squares best fit were identified as 4.01459e-0.0180804x and 13.2556e-0.00615859x. Decay of the syringomyelia followed an exponential model in both patients (R2 = 0.989582 and 0.948864). Conclusions. Three-dimensional analysis of syringomyelia resolution over time enables the kinetics to be estimated. This technique is yet to be validated in a large cohort. Because syringomyelia is the final common pathway for a number of different pathological processes, it is possible that this exponential only applies to syringomyelia related to treatment of Chiari malformation Type I.
机译：目的。在Chiari畸形的后脑减压后，脊髓空洞症的解决很普遍，但对于控制该过程的动力学知之甚少。作者试图确定脊髓空洞症的解决率。方法。确定了回顾性队列研究的患者，这些患者因术前宫颈或胸腔脊髓空洞症而进行的Chiari畸形I型后脑减压治疗。如果患者至少进行了3次神经影像学研究，详细说明了术后至少6个月的整个术前脊髓空洞症，则将其纳入研究。作者重建了3维的MR图像并计算了脊髓空洞症的体积。他们绘制了脊髓空洞症随时间变化的体积，并使用最小二乘法构建了回归模型。使用Akaike信息准则和贝叶斯信息准则来计算拟合的相对优度。计算确定系数R2（未调整和已调整），以描述统计模型所考虑的每个单独数据集中的可变性比例。结果。确定了两名符合入选标准的患者。最小二乘最佳拟合图被标识为4.01459e-0.0180804x和13.2556e-0.00615859x。两名患者的脊髓空洞衰变均遵循指数模型（R2 = 0.989582和0.948864）。结论对脊髓空洞症的分辨率进行三维分析，可以估算动力学。该技术尚待大量研究验证。由于脊髓空洞症是许多不同病理过程的最终通用途径，因此该指数可能仅适用于与治疗I型Chiari畸形有关的脊髓空洞症。

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