• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Non-pharmacological therapies in dementia. >Improvement of Functional Status in Alzheimer's Disease Patients after Cognitive Activation Therapy (CAT)
【24h】

Improvement of Functional Status in Alzheimer's Disease Patients after Cognitive Activation Therapy (CAT)

机译：认知激活疗法（CAT）后改善阿尔茨海默氏病患者的功能状态

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Non-pharmacological approaches have been shown to be useful in treating cognitive decline in dementia, however the functional impact of such protocols has not been fully established. The aim of the study is to throughly evaluate the effects in various functional domains of a specific therapeutic protocol called Cognitive Activation Therapy (CAT) by a direct assessment of abilities. Methods: CAT protocol was developed starting from previous experiences (Reality Orientation Therapy, Reminiscence and Re-motivation) performed within the frame of errorless learning principles, with the reinforcement of social health education. The treatment, divided into 18 sessions of 4 hours each, was organized in small groups of patients. In order to evaluate the effect on simple and complex abilities of everyday life the Direct Assessment of Functional Status (DAFS) was used at the beginning and at the end of each treatment. The activities evaluated by the DAFS were different from the abilities trained during the CAT. Cognitive changes and perceived health status were tested with MMSE and SF-12 respectively. Results: 206 patients in stable treatment with cholinesterase inhibitors (3 months minimum) were recruited (MMSE score 14-24). The CAT group (206) was compared to a control group (40) with similar age, gender, functional and cognitive status, and drug therapy. After CAT treatment we observed a statistically significant improvement (pO.OOOl) in the MMSE that went from score of 21.8 (t_0) to 23.3 (t_1) with a difference (A) of 1.5 points (t_1-t_0) and in the functional scale (DAFS) that increased from 62.5 (to) to 69.5 (t_1) with a difference (A) of 7 points. Physical SF12 and mental SF12 did not show any significant variation after treatment. In the control group the four scales were unchanged. Conclusion: CAT protocol was found effective to ameliorate not only cognition but also functional status of subjects with mild to moderate Alzheimer's Disease in addition to that obtained with pharmacological therapy only. In the CAT group with subjects with greater functional impairment at baseline, the improvement was particularly pronounced in abilities which are crucial for autonomy.
机译：简介：非药理学方法已被证明可用于治疗痴呆的认知功能下降，但此类方案的功能影响尚未完全确定。该研究的目的是通过对能力的直接评估来全面评估称为认知激活疗法（CAT）的特定治疗方案在各个功能域中的作用。方法：CAT协议是在无差错学习原则的框架内，根据先前的经验（现实取向疗法，怀旧和激励）而开发的，并加强了社会健康教育。该治疗分为小部分患者，分为18个疗程，每个疗程4小时。为了评估对日常生活中简单和复杂能力的影响，在每种治疗的开始和结束时均使用了功能状态直接评估（DAFS）。 DAFS评估的活动与CAT培训的能力不同。 MMSE和SF-12分别测试了认知变化和感知健康状况。结果：招募了206例胆碱酯酶抑制剂稳定治疗的患者（最少3个月）（MMSE评分14-24）。将CAT组（206）与具有相似年龄，性别，功能和认知状态以及药物治疗的对照组（40）进行比较。 CAT治疗后，我们观察到MMSE的统计学显着改善（p <0.001），从得分21.8（t_0）到23.3（t_1），差异（A）为1.5分（t_1-t_0），功能范围（DAFS）从62.5（to）增加到69.5（t_1），差异（A）为7点。治疗后身体SF12和精神SF12未显示任何明显变化。在对照组中，四个量表没有变化。结论：除了仅通过药物治疗获得的结果外，CAT方案还不仅可以改善轻度至中度阿尔茨海默氏病患者的认知，而且可以改善其功能状态。在基线时功能受损更大的受试者的CAT组中，对自主性至关重要的能力的改善尤为明显。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号