Granulocyte Differentiation Inducer,Hexapeptide HLDF-6,Decreases Cytotoxic Effect of Tumor Necrosis Factor on HL-60 Cell Line

N.V.Gibanova; T.V.Rakitina; V.M.Lipkin

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Granulocyte Differentiation Inducer,Hexapeptide HLDF-6,Decreases Cytotoxic Effect of Tumor Necrosis Factor on HL-60 Cell Line

机译：粒细胞分化诱导剂六肽HLDF-6降低肿瘤坏死因子对HL-60细胞的细胞毒作用

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The effect of hexapeptide HLDF-6,the granulocytic differentiation inducer,on the tumor necrosis factor alpha(TNF-alpha)-induced differentiation and apoptosis of human promyelocytic leukemia HL-60 cells has been investigated.Costimulation of HL-60 cells with HLDF-6 and TNF-alpha enhanced granulocyte differentiation,whereas the level of mono cyte differentiation remained unchanged;however,the cytotoxic action of TNF-alpha on these cells decreased.The protective effect of HLDF-6 peptide did not depend on activation of NF-KAPPA B(nuclear transcription factor).Since HLDF-6 peptide decreases the number of cells entering apoptosis caused by C2-ceramide,a mediator of TNF-induced apoptosis,and also reduces TNF-alpha-mediated activation of caspase-3,we have proposed the hypothesis that HLDF-6 increases resistance of HL-60 cells to the TNF-alpha cytotoxic effect due to inhibition of some stages of mitochondria-dependent apoptotic signaling.

机译：研究了六肽HLDF-6（粒细胞分化诱导剂）对肿瘤坏死因子α（TNF-α）诱导的人早幼粒细胞白血病HL-60细胞分化和凋亡的影响。 6和TNF-α增强了粒细胞的分化，而单核细胞分化的水平保持不变;但是，TNF-α对这些细胞的细胞毒性作用减弱了。HLDF-6肽的保护作用并不依赖于NF-KAPPA的激活由于HLDF-6肽减少了由C2神经酰胺（TNF诱导的细胞凋亡的介体）引起的进入凋亡的细胞数量，并且还减少了TNF-α介导的caspase-3激活，因此我们提出了假说HLDF-6增加了HL-60细胞对TNF-α细胞毒性作用的抗性，这是由于线粒体依赖性凋亡信号传导的某些阶段受到抑制。

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《Biochemistry》 |2007年第1期|共12页
作者
N.V.Gibanova; T.V.Rakitina; V.M.Lipkin;
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正文语种 eng
中图分类生物化学;
关键词
cell differentiation; apoptosis; peptide HLDF-6; TNF-alpha; HL-60 cell line; transcription factor NF-KAPPA B;

机译：细胞分化;凋亡;肽HLDF-6;TNF-alpha;HL-60细胞系;转录因子NF-KAPPA B;

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1. Granulocyte Differentiation Inducer,Hexapeptide HLDF-6,Decreases Cytotoxic Effect of Tumor Necrosis Factor on HL-60 Cell Line [J] . N.V.Gibanova, T.V.Rakitina, V.M.Lipkin Biochemistry . 2007,第1期

机译：粒细胞分化诱导剂六肽HLDF-6降低肿瘤坏死因子对HL-60细胞的细胞毒作用
2. Priming effects of tumor necrosis factor-α on production of reactive oxygen species during Toxoplasma gondii stimulation and receptor gene expression in differentiated HL-60 cells [J] . Kikuchi-UedaT., UbagaiT., OnoY. Journal of infection and chemotherapy: official journal of the Japan Society of Chemotherapy . 2013,第6期

机译：肿瘤坏死因子-α对弓形虫刺激过程中活性氧的产生及分化HL-60细胞受体基因表达的影响
3. Polar agents with differentiation inducing capacity potentiate tumor necrosis factor-mediated cytotoxicity in human myeloid cell lines. [J] . Depraetere S, Vanhaesebroeck B, Fiers W, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 1995,第1期

机译：具有分化诱导能力的极性剂增强人骨髓细胞系中肿瘤坏死因子介导的细胞毒性。
4. Orthopedic Implant Particle-Induced Tumor Necrosis Factor-a Production in Macrophage–Monocyte Lineage Cells Is Mediated by Nuclear Factor of Activated T Cells [C] . HIROSHI MINEMATSU, MIKE J. SHIN, AYSE B. CELIL AYDEMIR, Conference on Skeletal Biology and Medicine . 2007

机译：矫形植入物颗粒诱导的肿瘤坏死因子 - 巨噬细胞单核细胞谱系细胞的产生是由活化T细胞的核因子介导的
5. Factors shed by breast tumor cells, tumor necrosis factor alpha converting enzyme activities, and the generation of pro-tumor macrophages. [D] . Rego, Stephen Lee. 2013

机译：乳腺肿瘤细胞脱落的因子，肿瘤坏死因子α转换酶的活性以及促肿瘤巨噬细胞的产生。
6. Tumor necrosis factor alpha maintains the viability of murine epidermal Langerhans cells in culture but in contrast to granulocyte/macrophage colony-stimulating factor without inducing their functional maturation [O] . 1990

机译：肿瘤坏死因子α维持培养的小鼠表皮朗格汉斯细胞的活力但与粒细胞/巨噬细胞集落刺激因子相反却不诱导其功能成熟
7. Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin- induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation [O] . JB Weinberg, SN Mason, TS Wortham 1992

机译：抑制肿瘤坏死因子 - α（TNF-α）和白细胞介素-1β（IL-1β）信使RNA（MRNA）在HL-60白血病细胞中的表达通过戊氧化碱和地塞米松：对血清诱导的TNF-α和IL的解离-1βmRNA表达来自Acivicin诱导的单胞包分化
8. Interdependence of the Radioprotective Effects of Human Recombinant Interleukin 1alpha, Tumor Necrosis Factor alpha, Granulocyte Colony-Stimulating Factor, and Murine Recombinant Granulocyte-Macrophage Colony-Stimulating Factor [R] . Neta, R., Oppenheim, J. J., Douches, S. D. 1988

机译：人重组白细胞介素1α，肿瘤坏死因子α，粒细胞集落刺激因子和小鼠重组粒细胞 - 巨噬细胞集落刺激因子的辐射保护作用的相互依赖性

Granulocyte Differentiation Inducer,Hexapeptide HLDF-6,Decreases Cytotoxic Effect of Tumor Necrosis Factor on HL-60 Cell Line

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