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首页> 外文期刊>Nordic journal of psychiatry. >Effectiveness of buprenorphine maintenance treatment as compared to a syringe exchange program among buprenorphine misusing opioid-dependent patients.
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Effectiveness of buprenorphine maintenance treatment as compared to a syringe exchange program among buprenorphine misusing opioid-dependent patients.

机译：与滥用丁丙诺啡的阿片类药物依赖患者进行注射器交换计划相比，丁丙诺啡维持治疗的有效性。

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AIMS: To investigate the effectiveness of buprenorphine maintenance treatment (BMT) among opioid dependents who are mainly misusing buprenorphine intravenously. METHODS: The study was a prospective naturalistic follow-up with a non-randomized control group. In Finland, 30 opioid dependents reporting previous misuse of buprenorphine and participating in the outpatient BMT and 30 matched controls participating in a syringe exchange program (SEP) were followed. Based on the evidence for the superiority of maintenance treatment, randomization was not done. The effectiveness was evaluated by retention rate, European Addiction Severity Index (EuropASI) interviews, Beck Depression Inventory (BDI), visual analogue scale for quality of life (VAS) during the 2-year follow-up and mortality rates during the 3-year follow-up. Because of drop-outs in the SEP group, only the BMT group was interviewed at 24 months. RESULTS: At 3 months, the retention rate of the BMT group was 100% and of the SEP group 47%. At 12 months, the corresponding percentages were 83% and 37%. The total EuropASI composite score improved significantly only in the BMT group. In the BMT group, the BDI total score and VAS scales for quality of life improved significantly more than they did in the SEP group. During 3-year follow-up, four patients in the SEP died and none in the BMT. CONCLUSIONS: BMT appears to be an effective treatment for opioid dependents using mainly buprenorphine intravenously. On the other hand, bare SEP appears to result in high drop-out, not significant improvements and deaths.
机译：目的：研究在主要滥用静脉注射丁丙诺啡的阿片类药物依赖者中，丁丙诺啡维持治疗（BMT）的有效性。方法：本研究是对非随机对照组的一项前瞻性自然随访。在芬兰，追踪了30名报告曾滥用丁丙诺啡并参加门诊BMT的阿片类药物家属，以及30名参加了注射器更换计划（SEP）的匹配对照。根据维持治疗优越性的证据，未进行随机分组。通过保留率，欧洲成瘾严重性指数（EuropASI）访谈，贝克抑郁量表（BDI），2年随访期间的生活质量视觉模拟量表（VAS）和3年死亡率来评估有效性跟进。由于SEP组的辍学，在24个月时仅对BMT组进行了采访。结果：3个月时，BMT组的保留率为100％，SEP组的保留率为47％。在12个月时，相应的百分比分别为83％和37％。仅在BMT组中，EuropASI综合总评分显着提高。在BMT组，生活质量的BDI总分和VAS量表比SEP组显着改善。在3年的随访中，SEP中有4例患者死亡，而BMT中无一例死亡。结论：BMT似乎是主要通过静脉使用丁丙诺啡对阿片类药物依赖者的有效治疗方法。另一方面，裸露的SEP似乎会导致高辍学率，而不是明显的改善和死亡。

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