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首页> 外文期刊>Nordic journal of psychiatry. >Genetic vulnerability and premature death in schizophrenia spectrum disorders: a 28-year follow-up of adoptees in the Finnish Adoptive Family Study of Schizophrenia.
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Genetic vulnerability and premature death in schizophrenia spectrum disorders: a 28-year follow-up of adoptees in the Finnish Adoptive Family Study of Schizophrenia.

机译：精神分裂症谱系障碍的遗传脆弱性和过早死亡：芬兰精神分裂症收养家庭研究中的收养者28年随访。

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BACKGROUND: Excess mortality is widely reported among schizophrenia patients, but rarely examined in adoption study settings. AIM: We investigated whether genetic background plays a role in the premature death of adoptees with schizophrenia. METHODS: Mortality among 382 adoptees in the Finnish Adoptive Family Study of Schizophrenia was monitored from 1977 to 2005 through the national causes-of-death register. The sample covered 190 adoptees with a high genetic risk of schizophrenia (HR) and 192 with a low risk (LR). RESULTS: Overall mortality among the adoptees did not differ between the HR and LR groups, as 10% and 9% respectively had died during the follow-up, at mean ages of 45 and 46 years. Schizophrenia spectrum disorder was the most significant predictor of premature death in both groups, with dysfunction in the rearing family environment associated with mortality, unnatural deaths and suicides in the HR but not in the LR group. All the suicides involved HR cases. CONCLUSIONS: Mortality among the adoptees was not related to genetic factors but to environmental ones. The association of unnatural deaths and suicides with dysfunction in the rearing environment among the HR adoptees may indicate that they had a greater genetically determined vulnerability to environmental effects than their LR counterparts. The genetic and rearing environments can be disentangled in this setting because the biological parents give the offspring their genes and the adoptive parents give them their rearing environment. Our findings add to knowledge of the factors associated with the premature death of adoptees in mid-life.
机译：背景：在精神分裂症患者中广泛报道过高的死亡率，但很少在收养研究中进行检查。目的：我们调查了遗传背景是否在精神分裂症患者的过早死亡中起作用。方法：从1977年至2005年，通过国家死亡原因登记表对芬兰精神分裂症收养家庭研究中382名收养者的死亡率进行了监测。样本涵盖了190位精神分裂症遗传风险高的被收养者和192位低精神分裂症（LR）的被收养者。结果：HR和LR组之间，被收养者的总死亡率没有差异，因为在随访期间分别死亡的分别为10％和9％，平均年龄为45岁和46岁。精神分裂症谱系障碍是两组中过早死亡的最重要预测指标，在养育家庭环境中功能障碍与HR相关的死亡率，非自然死亡和自杀有关，而LR组则不然。所有的自杀都涉及人力资源案件。结论：被收养人的死亡率与遗传因素无关，而与环境因素有关。 HR受养者中饲养环境中非自然死亡和自杀与功能障碍的关联可能表明，与LR对应者相比，他们在遗传上确定的对环境影响的脆弱性更大。在这种情况下，遗传和饲养环境可能会被打乱，因为亲生父母会给后代提供基因，而养父母会给他们提供饲养环境。我们的发现增加了与中年收养者过早死亡相关的因素的知识。

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