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首页> 外文期刊>Nordic journal of psychiatry. >Early death and CSF monoamine metabolites in schizophrenia spectrum psychosis.
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Early death and CSF monoamine metabolites in schizophrenia spectrum psychosis.

机译：精神分裂症频谱性精神病的早期死亡和脑脊液单胺代谢产物。

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INTRODUCTION: Patients with schizophrenia have higher rates of mortality than the general population. Lower concentrations of the cerebrospinal fluid (CSF) monoamine metabolites homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) have been associated with suicidal, aggressive and impulsive behavior. Mortality has been suggested as a measure of impulsivity and a relationship between early death and lower concentrations of CSF monoamine metabolites has been reported but the studies are few with short periods of follow-up and small numbers. AIM: The objective of this study was to investigate a relationship between early death and concentrations of CSF 5-HIAA and HVA. METHODS: Three hundred and eighty-five inpatients with schizophrenia spectrum psychosis were lumbar punctured in a standardized manner and followed for a median of 26 years. Patients were searched to identify those who had died. Causes of death were obtained from the Causes of Death Register. RESULTS: During the time of follow-up, 97 patients died. Schizophrenia spectrum psychosis patients died at an earlier age from both natural and unnatural causes of death. No significant associations were found between CSF 5-HIAA and HVA concentrations and non-suicidal death. Attempted suicide was not a risk factor for non-suicidal death at younger age. CONCLUSION: Patients with schizophrenia spectrum psychosis die at an earlier age from both natural and unnatural causes of death. Attempted suicide is not a risk factor for non-suicidal death at younger age. Low concentrations of CSF HVA and 5-HIAA were not a risk factor for non-suicidal death at younger age in schizophrenia spectrum psychosis.
机译：简介：精神分裂症患者的死亡率高于一般人群。较低浓度的脑脊髓液（CSF）单胺代谢产物高香草酸（HVA）和5-羟基吲哚乙酸（5-HIAA）与自杀，攻击和冲动行为有关。有人建议使用死亡率来衡量冲动性，据报早死与脑脊液单胺代谢物浓度较低之间存在关系，但这项研究很少，随访时间短，数量少。目的：本研究的目的是研究早期死亡与脑脊液5-HIAA和HVA浓度之间的关系。方法：对358例精神分裂症频谱型精神病住院患者进行标准化腰椎穿刺，平均随访26年。对患者进行搜索以识别死亡者。死亡原因从死亡原因登记簿中获得。结果：在随访期间，有97例患者死亡。精神分裂症谱系精神病患者死于自然死亡和非自然死亡。在脑脊液5-HIAA和HVA浓度与非自杀死亡之间未发现显着关联。自杀未成年后非自杀死亡的危险因素。结论：精神分裂症频谱性精神病患者死于自然死亡和非自然死亡。未自杀未成年后非自杀死亡的危险因素。在精神分裂症频谱性精神病中，低浓度的CSF HVA和5-HIAA并非非自杀死亡的危险因素。

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