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首页> 外文期刊>Nordic journal of psychiatry. >Factors associated with subjective side-effects during clozapine treatment
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Factors associated with subjective side-effects during clozapine treatment

机译：氯氮平治疗期间与主观副作用相关的因素

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摘要

Objective: Clozapine is associated with subjectively unpleasant or clinically serious side-effects, which may affect treatment adherence. The aims of the study were to explore the association of clozapine+ norclozapine serum concentration and other factors with subjective side-effects in schizophrenia patients. Methods : In this cross-sectional study, 237 patients with a diagnosis of schizophrenia, schizo-affective or other non-organic psychoses completed the Liverpool University Neuroleptic Side Effect Rating Scale (LUNSERS), a self-report scale measuring side-effects of antipsychotics and a clinical questionnaire. Clozapine+ norclozapine serum concentration of 190 patients was measured. Of the patients 80 (33.7%) were on antipsychotic combination therapy. Results: Higher clozapine+ norclozapine concentrations were associated with the depression-anxiety factor of LUNSERS and antipsychotic combination treatments were associated with sympatichotonia-tension factor. Younger patients reported sedation more often than older patients. Conclusion: According to the present results, high clozapine concentrations were associated with depression -anxiety symptoms, but the causality remains unknown.
机译：目的：氯氮平具有主观上不愉快或临床上严重的副作用，可能影响治疗依从性。该研究的目的是探讨氯氮平+去氯氮平的血清浓度和其他因素与精神分裂症患者的主观副作用之间的关系。方法：在这项横断面研究中，诊断患有精神分裂症，精神分裂症或其他非有机性精神病的237例患者完成了利物浦大学精神病学副作用评定量表（LUNSERS），这是一种自我报告量表，用于衡量抗精神病药的副作用。和一份临床问卷。测量了190例患者的氯氮平+去氯氮平的血清浓度。患者中有80名（33.7％）接受抗精神病药物联合治疗。结果：较高的氯氮平+去氯氮平浓度与LUNSERS的抑郁-焦虑因素有关，而抗精神病药物联合治疗与交感神经紧张度-紧张因素有关。年轻的患者比年老的患者报告镇静的频率更高。结论：根据目前的结果，高氯氮平与抑郁-焦虑症状有关，但其因果关系仍然未知。

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