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首页> 外文期刊>Comprehensive psychiatry. >Association between subjective well-being and depressive symptoms in treatment-resistant schizophrenia before and after treatment with clozapine
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Association between subjective well-being and depressive symptoms in treatment-resistant schizophrenia before and after treatment with clozapine

机译：氯氮平治疗前后难治性精神分裂症患者的主观幸福感与抑郁症状之间的关系

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Background We examined the relationship between subjective well-being and depressive symptoms in patients with treatment-resistant schizophrenia before and after treatment with clozapine to contribute to the growing body of research regarding the determinants of patients' perspective of their own well-being in schizophrenia. Methods Forty patients with treatment-resistant schizophrenia were comprehensively evaluated for subjective well-being, schizophrenic symptoms, and depressive symptoms before and 8 weeks after the initiation of treatment with clozapine. Correlation analysis and Fisher's z-transformation statistics were performed. Results There were significant improvements in all Positive and Negative Syndrome Scale (PANSS) factor scores and Beck Depression Inventory (BDI) score over the treatment period (P <.05). Before clozapine administration, the subjective well-being score had significant negative correlations with the PANSS depression factor score (P <.05) and the BDI score (P <.05). After clozapine treatment, the subjective well-being score still had significant negative correlations with the PANSS depression factor score (P <.05) and the BDI score (P <.05) and no new associations emerged with treatment. Fisher's z-transformation statistics revealed that the correlations between the subjective well-being score and the depression score were not significantly different before and after clozapine treatment. Conclusions These results indicate that depressive symptoms are significantly associated with low subjective well-being in patients with treatment-resistant schizophrenia. The association was equally significant before and after treatment with clozapine, suggesting that the relationship does not change with clozapine treatment, even when depressive symptoms improve significantly, and that there may be a common pathophysiological basis for depressive symptoms and the subjective appraisal of well-being in schizophrenia.
机译：背景我们研究了氯氮平治疗前后难治性精神分裂症患者的主观幸福感与抑郁症状之间的关系，以促进有关患者自身精神分裂症幸福感决定因素的研究不断发展。方法对氯氮平治疗开始前和治疗后8周的40例难治性精神分裂症患者进行主观幸福感，精神分裂症症状和抑郁症状的综合评估。进行了相关分析和Fisher的z变换统计。结果在整个治疗期间，所有阳性和阴性综合征量表（PANSS）因子评分和贝克抑郁量表（BDI）评分都有显着改善（P <.05）。服用氯氮平之前，主观幸福感评分与PANSS抑郁因子评分（P <.05）和BDI评分（P <.05）呈显着负相关。氯氮平治疗后，主观幸福感评分仍与PANSS抑郁因子评分（P <.05）和BDI评分（P <.05）呈显着负相关，并且与治疗无新的关联。 Fisher的z转换统计数据表明，氯氮平治疗前后主观幸福感评分与抑郁评分之间的相关性无显着差异。结论这些结果表明，对难治性精神分裂症患者而言，抑郁症状与低主观幸福感显着相关。氯氮平治疗前后的相关性同样显着，表明即使在抑郁症状明显改善的情况下，氯氮平治疗也不会改变这种关系，并且抑郁症状和主观评估幸福感可能有共同的病理生理基础在精神分裂症。

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