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首页> 外文期刊>Nordic journal of psychiatry. >Is smoking linked to positive symptoms in acutely ill psychiatric patients?
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Is smoking linked to positive symptoms in acutely ill psychiatric patients?

机译：吸烟与精神病患者的阳性症状有关吗？

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Background: The self-medication hypothesis is commonly put forward to explain the high prevalence of smoking in psychiatric patients. However, studies supporting the self-medication hypothesis have most often been carried out on chronic patients stabilized by antipsychotics. Aim: Given that antipsychotics tend to erase psychiatric symptoms, the present study was undertaken on acutely ill patients usually receiving no medications, or on whom medications are ineffective. Methods: Participants were 492 consecutively hospitalized patients. They were evaluated the day of their hospitalization with the Brief Psychiatric Rating Scale (BPRS, 18 items). Urinary cotinine and creatinine were measured the morning following their hospitalization. The urinary cotinine/creatinine ratio and the cotinine/creatinineumber of cigarettes smoked per day ratio (nicotine extraction index) were calculated for each patient. Results: The positive symptoms subscale of the BPRS significantly correlated with smoking, whereas other BPRS subscales did not. In patients with mood disorder, the nicotine extraction index correlated with the positive symptoms, activation and hostility subscales, but not with the negative symptoms subscale. Analyses of individual BPRS items using the cotinine/creatinine ratio measure showed that smoking is positively associated with "unusual thought content" and "grandiosity" items and negatively associated with "guilt feeling", "depressed mood" and "motor retardation". Analyses of individual BPRS items using the nicotine extraction index showed a positive association only with "unusual thought content" and "grandiosity" items. Patients with schizophrenia extract more nicotine from cigarettes than other patients. Conclusion: In acutely ill psychiatric patients, smoking is linked with positive symptoms and not with negative symptoms.
机译：背景：自我用药假说通常被用来解释精神病患者吸烟的高流行。但是，大多数支持自我药物治疗假说的研究都是在抗精神病药稳定的慢性患者上进行的。目的：鉴于抗精神病药倾向于消除精神病症状，因此本研究针对通常不接受药物治疗或药物无效的急性病患者。方法：参加者为492名连续住院的患者。使用简短的精神病评定量表（BPRS，18个项目）对他们住院当天进行了评估。住院后第二天早晨测量尿中的可替宁和肌酐。计算每位患者的尿中可替宁/肌酐比值和可替宁/肌酐/每天吸烟量的比值（尼古丁提取指数）。结果：BPRS的阳性症状分量表与吸烟显着相关，而其他BPRS分量表则与吸烟无关。在情绪障碍患者中，尼古丁提取指数与阳性症状，激活和敌对性分量表相关，而与阴性症状分量表无关。使用可替宁/肌酐比值量度对单个BPRS项目进行的分析表明，吸烟与“异常的思想含量”和“超凡度”项目呈正相关，而与“内gui感”，“沮丧的情绪”和“运动迟缓”呈负相关。使用尼古丁提取指数对单个BPRS项目进行的分析显示，仅与“异常思想内容”和“雄辩”项目呈正相关。精神分裂症患者比其他患者从香烟中提取更多的尼古丁。结论：在精神病严重的精神病患者中，吸烟与阳性症状相关，而与阴性症状无关。

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