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首页> 外文期刊>Nordic journal of psychiatry. >The role of tumour necrosis factor alpha and soluble tumour necrosis factor alpha receptors in the symptomatology of schizophrenia
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The role of tumour necrosis factor alpha and soluble tumour necrosis factor alpha receptors in the symptomatology of schizophrenia

机译：肿瘤坏死因子α和可溶性肿瘤坏死因子α受体在精神分裂症症状中的作用

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Background Immunological mechanisms may be responsible for the development and maintenance of schizophrenia symptoms. Aim The aim of this study is to measure tumour necrosis factor-alpha (TNF-alpha), soluble tumour necrosis factor-alpha receptor I (sTNF-alpha RI), and soluble tumour necrosis factor-alpha receptor II (sTNF-alpha RII) levels in patients with schizophrenia and healthy individuals, and to determine their relationship with the symptoms of schizophrenia. Methods Serum TNF-alpha, sTNF-alpha RI and sTNF-alpha RII levels were measured. The Positive and Negative Syndrome Scale (PANSS) was administered for patients with schizophrenia (n = 35), and the results were compared with healthy controls (n = 30). Hierarchical regression analyses were undertaken to predict the levels of TNF-alpha, sTNF-alpha RI and sTNF-alpha RII. Results No significant difference was observed in TNF-alpha levels, but sTNF-alpha RI and sTNF-alpha RII levels were lower in patients with schizophrenia. Serum sTNF-alpha RI and sTNF-alpha RII levels were found to be negatively correlated with the negative subscale score of the PANSS, and sTNF-alpha RI levels were also negatively correlated with the total score of the PANSS. Smoking, gender, body mass index were not correlated with TNF-alpha and sTNF-alpha receptor levels. Conclusions These results suggest that there may be a change in antiinflammatory response in patients with schizophrenia due to sTNF-alpha RI and sTNF-alpha RII levels. The study also supports low levels of TNF activity in schizophrenia patients with negative symptoms.
机译：背景免疫机制可能与精神分裂症症状的发生和维持有关。目的本研究的目的是测量肿瘤坏死因子-α（TNF-alpha），可溶性肿瘤坏死因子-α受体I（sTNF-alpha RI）和可溶性肿瘤坏死因子-α受体II（sTNF-alpha RII）精神分裂症患者和健康个体的血脂水平，并确定他们与精神分裂症症状的关系。方法测定血清TNF-α，sTNF-alpha RI和sTNF-alpha RII水平。对精神分裂症患者（n = 35）进行阳性和阴性综合症量表（PANSS），并将结果与​​健康对照（n = 30）进行比较。进行了层次回归分析，以预测TNF-α，sTNF-αRI和sTNF-αRII的水平。结果精神分裂症患者的TNF-α水平无明显差异，但sTNF-αRI和sTNF-αRII水平较低。血清sTNF-alpha RI和sTNF-alpha RII水平与PANSS的负子量表得分呈负相关，而sTNF-alpha RI水平也与PANSS的总得分负相关。吸烟，性别，体重指数与TNF-α和sTNF-α受体水平无关。结论这些结果表明，由于sTNF-αRI和sTNF-αRII水平，精神分裂症患者的抗炎反应可能有所改变。该研究还支持具有阴性症状的精神分裂症患者的TNF活性低水平。

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