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Transcription Factories and Spatial Organization of Eukaryotic Genomes

机译：转录工厂和真核基因组的空间组织。

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摘要

The phenomenon of association of transcribed genes into so-called transcription factories and also the role of these associations in spatial organization of the eukaryotic genome are actively discussed in the modern literature. Some authors think that the association of transcribed genes into transcription factories constitutes a major factor supporting the function-dependent three-dimensional organization of the interphase genome. In spite of the obvious interest in the problem of spatial organization of transcription in the eukaryotic cell nucleus, the number of experimental studies-of transcriptional factories remains rather limited and the results of these studies are often contradictory. In the current review we have tried to critically re-evaluate the published experimental results that constitute the basis for current models and also the models themselves. We have especially analyzed the existing contradictions and attempted to explain them whenever possible. We also discuss new models that can explain the biological significance of clustering of transcribed genes and show possible mechanisms of the origin of transcription factories in the course of evolution.
机译：在现代文献中积极地讨论了转录的基因与所谓的转录工厂的缔合现象以及这些缔合在真核基因组空间组织中的作用。一些作者认为，转录基因与转录工厂的关联是支持相间基因组功能依赖性三维组织的主要因素。尽管对真核细胞核中转录的空间组织问题有明显的兴趣，但是转录工厂的实验研究数量仍然相当有限，而且这些研究的结果常常是矛盾的。在当前的审查中，我们试图严格地重新评估已发布的实验结果，这些结果构成了当前模型以及模型本身的基础。我们特别分析了现有的矛盾，并试图尽可能地解释它们。我们还讨论了新的模型，这些模型可以解释转录的基因簇的生物学意义，并显示进化过程中转录工厂起源的可能机制。

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