SYNTHESIS AND POTENT ANTI-LEUKEMIC ACTIVITY OF NOVEL 5 '-DEOXYCARBOCYCLIC C-NUCLEOSIDE PHOSPHONIC ACIDS

Kim Eunae; Hong Joon Hee

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SYNTHESIS AND POTENT ANTI-LEUKEMIC ACTIVITY OF NOVEL 5 '-DEOXYCARBOCYCLIC C-NUCLEOSIDE PHOSPHONIC ACIDS

机译：5'-脱氧碳环C-核苷磷酸的合成及潜在的抗白血病活性

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The first synthetic route to 5-deoxycarbocyclic C-nucleoside [9-deazaadenosine, (pyrrolo[3,2-d]pyrimidine)] phosphonic acids from commercially available 1,4-dihydroxy-2-butene was described. The key C-C bond formation from cyclopentanone to base precursor was performed using Knoevenagel-type condensation. Synthesized C-nucleoside phosphonic acids were tested for anti-HIV activity as well as anti-leukemic activity. They showed moderate cytotoxicity derived anti-HIV activity and anti-leukemic activity.

机译：描述了从可商购的1，4-二羟基-2-丁烯到5-脱氧碳环C-核苷[9-脱氮杂腺苷，（吡咯并[3，2-d]嘧啶）]膦酸的第一合成路线。从环戊酮到基础前体的关键C-C键形成是使用Knoevenagel型缩合进行的。测试了合成的C-核苷膦酸的抗HIV活性以及抗白血病活性。他们显示出中等的细胞毒性衍生的抗HIV活性和抗白血病活性。

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《Nucleosides, nucleotides and nucleic acids》 |2015年第12期|共16页
作者
Kim Eunae; Hong Joon Hee;
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正文语种 eng
中图分类生物化学;
关键词
Antiviral agent; anti-leukemic agent; C-nucleoside; Knoevenagel reaction;

机译：抗病毒药;抗白血病药;C-核苷;Knoevenagel反应;

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专利

1. SYNTHESIS AND POTENT ANTI-LEUKEMIC ACTIVITY OF NOVEL 5 '-DEOXYCARBOCYCLIC C-NUCLEOSIDE PHOSPHONIC ACIDS [J] . Kim Eunae, Hong Joon Hee Nucleosides, nucleotides and nucleic acids . 2015,第10a12期

机译：5'-脱氧碳环C-核苷磷酸的合成及潜在的抗白血病活性
2. Synthesis and Potent Anti-leukemic Activity of Novel 5 '-Norcarbocyclic C-nucleoside Phosphonic Acids [J] . Kim Seyeon, Kim Eunae, Oh Chang-Hyun, Bulletin of the Korean Chemical Society . 2014,第12期

机译：新型5'-N-碳环C-核苷膦酸的合成及抗白血病活性
3. SYNTHESIS OF NOVEL 4 '-TRIFLUOROMETHYL-5 '-NORCARBOCYCLIC C-NUCLEOSIDE PHOSPHONIC ACIDS AS POTENT ANTI-LEUKEMIC AGENTS [J] . Kim Seyeon, Hong Joon Hee Nucleosides, nucleotides and nucleic acids . 2015,第10a12期

机译：新型4'-三氟甲基-5'-正碳环C-核苷磷酸作为强效抗白血病药物的合成
4. Design and Synthesis of New Potent Melanocortin Peptides with Candidacidal Activity [C] . Luigia Auriemma, Stefania Malfi, Salvatore Di Maro American Peptide Symposium . 2009

机译：念珠菌活性的新有效素质蛋白肽的设计与合成
5. The design, synthesis, and use of phosphonic acids for the surface modification of metal oxides. [D] . Hotchkiss, Peter J. 2009

机译：膦酸的设计，合成和用于金属氧化物的表面改性。
6. Synthesis and in vitro Evaluation of 3H-Pyrrolo32-f-quinolin-9-one Derivatives That Show Potent and Selective Anti-leukemic Activity [O] . Dr. Maria Grazia Ferlin, Dr. Roberta Bortolozzi, Dr. Paola Brun, -1

机译：3H-Pyrrolo的合成和体外评价32-F -quinolin-9-一种衍生物显示有效和选择性抗白血病活动
7. Synthesis and in vitro evaluation of 3H-pyrrolo[3,2-f[quinolin-9-one derivatives that show potent and selective anti-leukemic activity [O] . FERLIN MG, BORTOLOZZI R, BRUN P, 2010

机译：具有有效和选择性抗白血病活性的3H-吡咯并[3,2-f [喹啉-9-一]衍生物的合成和体外评价

SYNTHESIS AND POTENT ANTI-LEUKEMIC ACTIVITY OF NOVEL 5 '-DEOXYCARBOCYCLIC C-NUCLEOSIDE PHOSPHONIC ACIDS

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