Efficient synthesis of 2'-deoxynucleoside 3'-C-phosphonates: reactivity of geminal hydroxyphosphonate moiety.

Kralikova S; Budesinsky M; Masojidkova M; Rosenberg I

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Efficient synthesis of 2'-deoxynucleoside 3'-C-phosphonates: reactivity of geminal hydroxyphosphonate moiety.

机译：2'-脱氧核苷3'-C-膦酸酯的高效合成：双羟基膦酸酯部分的反应性。

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In this report we present a novel, simple way for the synthesis of 3'-C-phosphonate derivatives of all four basic 2'-deoxynucleosides in both fully protected and deprotected forms. The reactivity of the geminal hydroxy phosphonate moiety located at the 3'-carbon atom of the nucleoside was studied with respect to the use of this type of nucleoside phosphonic acid for the preparation of short oligonucleotides, namely, dinucleoside monophosphate analogues.

机译：在本报告中，我们提出了一种新颖，简单的方法，用于以完全保护和脱保护的形式合成所有四个基本2'-脱氧核苷的3'-C-膦酸酯衍生物。关于使用这种类型的核苷膦酸制备短寡核苷酸，即二核苷单磷酸类似物，研究了位于核苷的3'-碳原子处的双羟基膦酸酯部分的反应性。

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《Nucleosides, nucleotides and nucleic acids》 |2000年第7期|共25页
作者
Kralikova S; Budesinsky M; Masojidkova M; Rosenberg I;
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正文语种 eng
中图分类细胞形态学;
关键词
DNA; Deoxyribonucleosides; Phosphonic Acids; 脱氧核糖核苷类; 膦酸类;

机译：DNA;Deoxyribonucleosides;Phosphonic Acids;脱氧核糖核苷类;膦酸类;

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1. Efficient synthesis of 2'-deoxynucleoside 3'-C-phosphonates: reactivity of geminal hydroxyphosphonate moiety. [J] . Kralikova S, Budesinsky M, Masojidkova M, Nucleosides, nucleotides and nucleic acids . 2000,第7期

机译：2'-脱氧核苷3'-C-膦酸酯的高效合成：双羟基膦酸酯部分的反应性。
2. Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC [J] . Wanat Przemyslaw, Walczak Sylwia, Wojtczak Blazej A., Organic letters . 2015,第12期

机译：核苷二磷酸和三磷酸的乙炔基，2-丙炔基和3-丁炔基C-膦酸酯的类似物：在CuAAC中的合成和反应性
3. Iron(II) complexes containing the 2,6-bis-iminopyridyl moiety. Synthesis, characterization, reactivity, and DNA binding [J] . Shaban Shaban Y., El-Shafai Nagi, Mansour Hanaa, Journal of Coordination Chemistry . 2015,第11a12期

机译：含2，6-双亚氨基吡啶基部分的铁（II）配合物。合成，表征，反应性和DNA结合
4. Substrate Promiscuity of Pyruvate Kinase on Various Deoxynucleoside Diphosphates for Synthesis of Deoxynucleoside Triphosphates [C] . . 2008

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5. Synthesis of peptide-alpha-phenylthioesters using a solid support with a photoreactive nitroindoline moiety. [D] . Pardo, Andrew. 2014

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6. Synthesis and nucleophilic reactivity of a series of glutathione analogues modified at the gamma-glutamyl moiety. [O] . A E Adang, A J Duindam, J Brussee, 1988

机译：一系列在γ-谷氨酰基部分修饰的谷胱甘肽类似物的合成和亲核反应性。
7. Sulphamic Acid: an Efficient Catalyst for the Synthesis of α-HydroxyPhosphonates Using Ultrasound Irradiation [O] . 2009

机译：磺胺酸：使用超声辐射合成α-羟基膦酸盐的有效催化剂

Efficient synthesis of 2'-deoxynucleoside 3'-C-phosphonates: reactivity of geminal hydroxyphosphonate moiety.

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