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首页> 外文期刊>Nucleus >Csi1 illuminates the mechanism and function of Rabl configuration
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Csi1 illuminates the mechanism and function of Rabl configuration

机译:Csi1阐明了Rabl配置的机制和功能

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摘要

The nuclear envelope not only compartmentalizes the genome but is also home to the SUN-KASH domain proteins, which play essential roles both in genome organization and in linking the nucleus to the cytoskeleton. In interphase fission yeast cells, centromeres are clustered near the nuclear periphery. A recent report demonstrates that the inner nuclear membrane SUN domain protein Sadl and a novel protein Csi1 connect centromeres to the nuclear envelope and that centromere clustering during interphase is critical for the efficient capture of kinetochores by microtubules during mitosis.
机译:核被膜不仅分隔基因组,而且还是SUN-KASH域蛋白的宿主,SUN-KASH域蛋白在基因组组织以及将核与细胞骨架连接中都起着重要作用。在相间裂变酵母细胞中,着丝粒聚集在核外围附近。最近的一份报告表明,核内膜SUN结构域蛋白Sadl和一种新型蛋白Csi1将着丝粒连接到核膜上,中间相中的着丝粒簇对有丝分裂中微管有效捕获动植物至关重要。

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