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Unraveling the mechanisms of chromatin fibril packaging

机译：染色质原纤维包装的机理

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Recent data indicate that eukaryotic chromosomes are organized into Topologically Associating Domains (TADs); however, the mechanisms underlying TAD formation remain obscure. Based on the results of Hi-C analysis performed on 4 Drosophila melanogaster cell lines, we have proposed that specific properties of nucleosomes in active and repressed chromatin play a key role in the formation of TADs. Our computer simulations showed that the ability of "inactive" nucleosomes to stick to each other and the lack of such ability in "active" nucleosomes is sufficient for spatial segregation of these types of chromatin, which is revealed in the Hi-C analysis as TAD/inter-TAD partitioning. However, some Drosophila and mammalian TADs contain both active and inactive chromatin, a fact that does not fit this model. Herein, we present additional arguments for the model by postulating that transcriptionally active chromatin is extruded on the surface of a TAD, and discuss the possible impact of this organization on the enhancer-promoter communication and on the segregation of TADs.
机译：最近的数据表明，真核染色体被组织成拓扑关联域（TAD）。但是，TAD形成的基础机制仍然不清楚。基于对4个果蝇果蝇细胞系进行的Hi-C分析的结果，我们提出了活性和阻抑染色质中核小体的特定特性在TAD的形成中起关键作用。我们的计算机模拟表明，“非活性”核小体相互粘附的能力以及“活性”核小体中缺乏这种能力足以对这些类型的染色质进行空间分离，这在Hi-C分析中以TAD的形式显示出来。 / inter-TAD分区。但是，一些果蝇和哺乳动物TAD既包含活性染色质，也包含非活性染色质，这一事实不适合该模型。在这里，我们通过假设转录活性染色质被挤出到TAD的表面上，为模型提供了更多的论据，并讨论了该组织对增强子-启动子通讯和TAD分离的可能影响。

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