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The role of lamin B1 for the maintenance of nuclear structure and function

机译：核纤层蛋白B1在维持核结构和功能中的作用

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摘要

Lamins constitute an integral structural component of the nuclear lamina. However, their impact on the structure and stability of chromosome territories, and on the regulation of gene expression is explored to a lesser extent. By 3D-FISH, Camps and colleagues showed that lamin B1 (LMNB1) is required for proper chromosome condensation in interphase nuclei, and deficiency of LMNB1 triggers the relocation of the epigenetic mark of facultative heterochromatin, H3K27me3, toward the interior of the nucleus. Additionally, LMNB1 repression slowed cellular growth due to S-phase delays and increased genomic instability. Finally, silencing of LMNB1 resulted in enlarged nuclear speckles and in extensive changes in alternative splicing of multiple genes. Altogether, the data suggest a central role of LMNB1 for the condensation of chromosome territories, for the distribution of heterochromatin, and for the regulation of gene expression and splicing.
机译：薄层构成核薄层的组成部分。但是，它们对染色体区域的结构和稳定性以及对基因表达的调节的影响程度较小。坎普斯及其同事通过3D-FISH研究表明，层间蛋白B1（LMNB1）是相间核中染色体正确凝结所必需的，而LMNB1的缺乏会触发兼性异染色质H3K27me3的表观遗传标记向核内部的重新定位。此外，由于S期延迟和基因组不稳定，LMNB1阻滞减慢了细胞的生长。最终，LMNB1沉默导致核斑点增加，多个基因的可变剪接发生广泛变化。总之，数据表明LMNB1在染色体区域的凝缩，异染色质的分布以及基因表达和剪接的调控中起着核心作用。

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