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首页> 外文期刊>Nutrition >Central and peripheral regulation of feeding and nutrition by the mammalian circadian clock. Implications for nutrition during manned space flight.
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Central and peripheral regulation of feeding and nutrition by the mammalian circadian clock. Implications for nutrition during manned space flight.

机译：哺乳动物生物钟对食物和营养的中枢和外围调节。载人航天飞行对营养的影响。

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摘要

Circadian clocks have evolved to predict and coordinate physiologic processes with the rhythmic environment on Earth. Space studies in non-human primates and humans have suggested that this clock persists in its rhythmicity in space but that its function is altered significantly in long-term space flight. Under normal circumstances, the clock is synchronized by the light-dark cycle via the retinohypothalamic tract and the suprachiasmatic nucleus. It is also entrained by restricted feeding regimes via a suprachiasmatic nucleus-independent circadian oscillator. The site of this suboscillator (or oscillators) is not known, but new evidence has suggested that peripheral tissues in the liver and viscera may express circadian clock function when forced to do so by restricted feeding schedules or other homeostatic disruptions. New research on the role of the circadian clock in the control of feeding on Earth and in space is warranted.
机译：昼夜节律时钟已经演变为预测和协调生理过程与地球上有节奏的环境。在非人类灵长类动物和人类中进行的空间研究表明，该时钟在空间中具有规律性，但在长期太空飞行中其功能会发生重大变化。在正常情况下，时钟通过视网膜下丘脑束和视交叉上核由明暗循环同步。它也通过跨视神经上不依赖核的昼夜节律振荡器被限制的进食方式所夹带。该次振荡器（或振荡器）的位置尚不清楚，但新证据表明，由于进食时间表受限或其他体内平衡干扰而迫使肝脏和内脏的外周组织表达昼夜节律功能。有必要对生物钟在控制地球和太空中的食物中的作用进行新的研究。

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