...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biological & pharmaceutical bulletin >Relationship between the Anchor Structure of the Galactosyl Ligand for Liposome Modification and Accumulation in the Liver
【24h】

Relationship between the Anchor Structure of the Galactosyl Ligand for Liposome Modification and Accumulation in the Liver

机译：半乳糖基配体的锚结构与脂质体修饰和肝脏蓄积的关系

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Liposomes which have been modified with (8-hexadecanoylamido-3,6-dioxaoctyl)-/}-D-galactose (Gal-t-pa), a straight chain palmitoyl derivative, and are composed of dipahnitoylphosphatidylcholine (DPPC), cholesterol (CH), and dicetyl phosphate (DCP) at a ratio of 10:10:1, showed the same accumulation in the liver as the control liposome. Also, liposomes which have been modified with {8-(2-hexadecyloctadccanoylamido)-3,6-dioxaoctyl}-/J-D-galactoside (Gal-t-psa) showed remarkable accumulation in the liver. The accumulation of liposomes modified with galactose derivatives in the rat liver differed markedly according to the anchor structure. To clarify the cause of this finding, we produced [3H]inulin entrapped [14C]Gal-t-pa modified double label liposomes and evaluated changes in their rat plasma concentration, distribution in the organs, and the in vitro interaction with rat plasma. [14C]Gal-t-pa on the liposome surface bound to serum albumin and was released, resulting in no accumulation in the liver. In addition, sialic acid palmitoyl derivatives and glucuronic acid palmitoyl derivatives behaved similarly. As with the galactose derivatives, they also bound to serum albumin, being released from liposomes. These results suggest that adequate attention should be paid to the anchor structure of the ligand, in order to incorporate a recognition element into liposomes for transport to cells.
机译：脂质体由直链棕榈酰基衍生物（8-十六烷酰胺基-3,6-二氧杂辛基）-/}-D-半乳糖（Gal-t-pa）修饰，并且由二苯甲酰基磷脂酰胆碱（DPPC），胆固醇（CH ）和磷酸二鲸蜡酯（DCP）以10：10：1的比例在肝脏中显示出与对照脂质体相同的积累。而且，已经用{8-（2-十六烷基十八烷基己酰胺基）-3，6-二氧杂辛基}-/ J-D-半乳糖苷（Gal-t-psa）修饰的脂质体在肝脏中显示出显着的积累。根据锚结构，用半乳糖衍生物修饰的脂质体在大鼠肝脏中的积累差异显着。为了阐明这一发现的原因，我们生产了[3H]菊粉包埋的[14C] Gal-t-pa修饰的双标签脂质体，并评估了它们在大鼠血浆中的浓度，器官中的分布以及与大鼠血浆的体外相互作用的变化。脂质体表面的[14C] Gal-t-pa与血清白蛋白结合并被释放，导致肝脏中没有积累。另外，唾液酸棕榈酰衍生物和葡萄糖醛酸棕榈酰衍生物表现相似。与半乳糖衍生物一样，它们也结合从脂质体释放的血清白蛋白。这些结果表明，应充分注意配体的锚定结构，以便将识别元件掺入脂质体中以转运至细胞。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号