...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nutrition >Angiotensinogen gene polymorphisms and food-intake behavior in young, normal female subjects in Japan
【24h】

Angiotensinogen gene polymorphisms and food-intake behavior in young, normal female subjects in Japan

机译：日本年轻，正常女性受试者的血管紧张素原基因多态性和食物摄入行为

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: We examined whether angiotensinogen (AGT) gene polymorphisms are associated with food preferences in young, normal female subjects. Methods: Fifty-two young, normal female subjects (21-22 y old) were recruited. After a 12-h fast, blood samples were obtained to examine the AGT gene polymorphisms (rs699 and rs7079), angiotensin-converting enzyme (ACE) insertion (I)/deletion (D), and adrenergic β3 receptor (ADRB3) gene polymorphisms (rs4994). A trained dietitian interviewed the participants to determine the portion size and frequency of food eaten for 1 wk by using the established questionnaire FFQg 3.0. Results: The genotypes of the AGT Met235Thr polymorphisms were TT:TC:CC = 2:19:31 (T:C = 0.22:0.78). The genotypes of AGT rs7079 were CC:CA:AA = 26:21:5 (C:A = 0.70:0.30), and those of ACE were DD:. DI:. II = 5:28:19 (D/. I = 0.37:0.63). The genotypes of ADRB3 Trp64Arg were TT:TC:CC = 38:11:3 (T:C = 0.84:0.16). The total caloric intake was greater for those with the MM/MT genotype of AGT Met235Thr than for those with the TT genotype (1993 versus 1698 kcal/d, P < 0.05). The consumption of total lipids, cholesterol, and unsaturated free fatty acids was also higher in those with the MM/MT genotype of AGT Met235Thr than in those with the TT genotype. However, the AGT polymorphism (rs7079) and the ACE I/. D were not associated with food preferences. In contrast, the subjects with ADRB3 Trp64 tended to show a high energy intake and preferences for proteins and lipids including fatty acids and cholesterol. They ate more fish and meat. Multiple regression analysis showed that the energy intake in subjects with the MM/MT genotype was independently determined by total lipids (B = 11.7, P < 0.0001) and carbohydrates (B = 4.6, P < 0.0001). Conclusions: The AGT Met235Thr polymorphism was significantly associated with a higher caloric intake owing to total fat and carbohydrate consumption.
机译：目的：我们研究了血管紧张素原（AGT）基因多态性是否与年轻，正常女性受试者的饮食偏好有关。方法：招募了52名年轻，正常的女性受试者（21-22岁）。禁食12小时后，获得血液样本以检查AGT基因多态性（rs699和rs7079），血管紧张素转换酶（ACE）插入（I）/缺失（D）和肾上腺素β3受体（ADRB3）基因多态性（ rs4994）。训练有素的营养师采访了参与者，以使用已建立的问卷FFQg 3.0确定1周内所食用食物的份量和频率。结果：AGT Met235Thr多态性的基因型为TT：TC：CC = 2:19:31（T：C = 0.22：0.78）。 AGT rs7079的基因型为CC：CA：AA = 26：21：5（C：A = 0.70：0.30），而ACE的基因型为DD:。 DI： II = 5:28:19（D /。I = 0.37：0.63）。 ADRB3 Trp64Arg的基因型为TT：TC：CC = 38：11：3（T：C = 0.84：0.16）。 MM / MT基因型的AGT Met235Thr的总热量摄入量大于TT基因型的总热量摄入（1993年vs 1698 kcal / d，P <0.05）。 MM / MT基因型的AGT Met235Thr的总脂质，胆固醇和不饱和游离脂肪酸的消耗也比TT基因型的高。但是，AGT多态性（rs7079）和ACE I /。 D与食物偏好无关。相反，患有ADRB3 Trp64的受试者倾向于表现出高能量摄入，并且偏爱蛋白质和脂质（包括脂肪酸和胆固醇）。他们吃了更多的鱼和肉。多元回归分析表明，MM / MT基因型受试者的能量摄入由总脂质（B = 11.7，P <0.0001）和碳水化合物（B = 4.6，P <0.0001）独立确定。结论：由于脂肪和碳水化合物的总消耗，AGT Met235Thr多态性与较高的卡路里摄入量显着相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号