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首页> 外文期刊>Nutrition and Cancer: An International Journal >Suppressive effect of low amounts of safflower and perilla oils on diethylnitrosamine-induced hepatocarcinogenesis in male F344 rats.
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Suppressive effect of low amounts of safflower and perilla oils on diethylnitrosamine-induced hepatocarcinogenesis in male F344 rats.

机译：少量的红花和紫苏油对二乙基亚硝胺诱导的雄性F344大鼠肝癌发生的抑制作用。

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We have investigated the modulating effects of low amounts of dietary oils rich in polyunsaturated fatty acids (PUFA) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in male F344 rats. A total of 112 animals were divided into eight groups. Groups 1-4 were given drinking water containing 40 ppm DEN for five weeks. Groups 5-8 served as controls without DEN treatment. Groups 1 and 5 were fed a basal diet containing 5% beef tallow, Groups 2 and 6 were fed a 5% olive oil diet, Groups 3 and 7 were fed a 5% safflower oil diet, and Groups 4 and 8 were fed a 5% perilla oil diet for 21 weeks, starting 1 week before DEN exposure. Beef tallow, olive oil, safflower oil, and perilla oil are rich in saturated fatty acids, a monounsaturated fatty acid, n-6 PUFA, and n-3 PUFA, respectively. All rats were killed 20 weeks after the start of the experiment. Incidences of hepatocellular adenoma and carcinoma were 100% in DEN-treated groups, irrespective of dietary oils. Multiplicities of adenomas in Groups 3 and 4 were significantly (p < 0.05) lower than in Groups 1 and 2. Multiplicity of carcinoma in Group 3 was significantly (p < 0.05) lower than in Group 1. Mean volumes of placental glutathione S-transferase-positive foci per liver and the number of argyrophilic nucleolar organizer region proteins per nucleus in the liver tumors were significantly (p < 0.05) lower in Groups 3 and 4 than in Groups 1 and 2. ras mRNA expression in liver neoplasms was also suppressed significantly (p < 0.05) in Groups 3 and 4 compared with Groups 1 and 2. Significantly (p < 0.05) higher levels of n-6 and n-3 PUFA in the phospholipid fraction of the liver were found in Groups 3 and 4, respectively, than in the other groups. In contrast, a significantly (p < 0.05) decrease in monounsaturated fatty acid was observed in Groups 3 and 4 compared with Groups 1 and 2. These results suggest that safflower oil and perilla oil, rich in n-6 and n-3 PUFA, respectively, alter the membrane fatty acid composition of the liver and suppress the development of liver cell carcinoma in rats.
机译：我们已经研究了低含量的富含多不饱和脂肪酸（PUFA）的食用油对二乙基亚硝胺（DEN）诱导的雄性F344大鼠肝癌发生的调节作用。总共112只动物被分成八组。 1-4组接受了含40 ppm DEN的饮用水，持续了五周。 5-8组作为未进行DEN治疗的对照。第1组和第5组饲喂含有5％牛脂的基础饮食，第2组和第6组饲喂5％橄榄油饮食，第3组和第7组饲喂5％红花油饮食，第4组和第8组饲喂5种饮食。从DEN暴露前1周开始的％紫苏油饮食，为期21周。牛脂，橄榄油，红花油和紫苏油分别富含饱和脂肪酸，单不饱和脂肪酸，n-6 PUFA和n-3 PUFA。在实验开始20周后将所有大鼠杀死。 DEN治疗组的肝细胞腺瘤和癌的发生率均为100％，而与膳食油无关。第3组和第4组腺瘤的多重性显着（p <0.05）比第1组和第2组低。第3组的癌瘤多重性显着（p <0.05）与第1组相比低。胎盘谷胱甘肽S-转移酶的平均体积组3和4中，肝肿瘤中每个肝脏的阳性阳性灶和每个核中的嗜酸性核仁组织者区域蛋白的数量均明显低于组1和2（p <0.05）。肝肿瘤中的ras mRNA表达也得到了显着抑制。与第1组和第2组相比，第3和第4组中的（p <0.05）。分别在第3和第4组中，肝脏磷脂中n-6和n-3 PUFA的含量显着较高（p <0.05）。 ，而不是其他组。相反，与第1组和第2组相比，第3组和第4组的单不饱和脂肪酸显着降低（p <0.05）。这些结果表明，富含n-6和n-3 PUFA的红花油和紫苏油，分别改变肝脏的膜脂肪酸组成并抑制大鼠肝细胞癌的发展。

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