...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nutrition and Cancer: An International Journal >Vitamin E succinate induces apoptosis in human prostate cancer cells: role for Fas in vitamin E succinate-triggered apoptosis.
【24h】

Vitamin E succinate induces apoptosis in human prostate cancer cells: role for Fas in vitamin E succinate-triggered apoptosis.

机译：维生素E琥珀酸酯诱导人前列腺癌细胞凋亡：Fas在维生素E琥珀酸酯触发的细胞凋亡中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The apoptosis-triggering properties of vitamin E succinate (VES, RRR-alpha-tocopheryl succinate) for human LNCaP and PC-3 prostate carcinoma cells and normal PrEC human prostate epithelial cells were investigated. LNCaP and PC-3 cells were sensitive to VES-induced apoptosis, with 100% and 60% of cells undergoing apoptosis after three days of treatment with 10 micrograms of VES/ml, respectively. PrEC cells were resistant to VES-induced apoptosis. Treatment of prostate cells with agonistic anti-Fas antibody triggered apoptosis in approximately 50% of PC-3 cells within 48 hours, whereas LNCaP and PrEC cells were resistant. Prostate cells simultaneously treated with VES and agonistic anti-Fas antibodies revealed 1) no effect on PrEC cells, 2) an additive effect on Fas-sensitive PC-3 cells, and 3) a synergistic effect on LNCaP cells. VES treatment of LNCaP cells caused depletion of cytosolic 43-kDa Fas, enhanced membrane levels of 43-kDa Fas, and induced Fas sensitivity. PC-3 cells expressed high levels of membrane 43-kDa Fas that were enhanced by VES treatments. Fas ligand expression by LNCaP cells was enhanced by VES treatments. In summary, VES triggers apoptosis in human prostate carcinoma cells but not normal prostate cells in vitro, and VES modulates Fas signaling.
机译：研究了维生素E琥珀酸酯（VES，RRR-α-生育酚琥珀酸酯）对人LNCaP和PC-3前列腺癌细胞以及正常PrEC人前列腺上皮细胞的促凋亡特性。 LNCaP和PC-3细胞对VES诱导的凋亡敏感，分别用10微克VES / ml处理三天后，分别有100％和60％的细胞发生凋亡。 PrEC细胞对VES诱导的细胞凋亡具有抗性。用激动性抗Fas抗体处理前列腺细胞可在48小时内触发约50％的PC-3细胞凋亡，而LNCaP和PrEC细胞具有抗性。同时用VES和激动性抗Fas抗体处理的前列腺细胞显示1）对PrEC细胞无影响，2）对Fas敏感PC-3细胞的加性影响，和3）对LNCaP细胞的协同作用。 VES处理LNCaP细胞会导致细胞溶质43-kDa Fas耗尽，增强43-kDa Fas的膜水平，并诱导Fas敏感性。 PC-3细胞表达高水平的膜43-kDa Fas，而VES处理可增强这种水平。 VES处理可增强LNCaP细胞的Fas配体表达。总之，VES在体外触发人前列腺癌细胞的凋亡，但不触发正常前列腺细胞的凋亡，并且VES调节Fas信号传导。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号