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首页> 外文期刊>Cell metabolism >Cardiotrophin-1 is a key regulator of glucose and lipid metabolism.
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Cardiotrophin-1 is a key regulator of glucose and lipid metabolism.

机译：心肌营养素1是葡萄糖和脂质代谢的关键调节剂。

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摘要

Cardiotrophin-1 (CT-1) is a member of the gp130 family of cytokines. We observed that ct-1(-/-) mice develop mature-onset obesity, insulin resistance, and hypercholesterolemia despite reduced calorie intake. Decreased energy expenditure preceded and accompanied the development of obesity. Acute treatment with rCT-1 decreased blood glucose in an insulin-independent manner and increased insulin-stimulated AKT phosphorylation in muscle. These changes were associated with stimulation of fatty acid oxidation, an effect that was absent in AMPKalpha2(-/-) mice. Chronic rCT-1 treatment reduced food intake, enhanced energy expenditure, and induced white adipose tissue remodeling characterized by upregulation of genes implicated in the control of lipolysis, fatty acid oxidation, and mitochondrial biogenesis and genes typifying brown fat phenotype. Moreover, rCT-1 reduced body weight and corrected insulin resistance in ob/ob and in high-fat-fed obese mice. We conclude that CT-1 is a master regulator of fat and glucose metabolism with potential applications for treatment of obesity and insulin resistance.
机译：心肌营养素1（CT-1）是gp130细胞因子家族的成员。我们观察到ct-1（-/-）小鼠尽管卡路里摄入减少，但仍会发育成熟的肥胖症，胰岛素抵抗和高胆固醇血症。在肥胖发生之前，伴随着能量消耗的减少。用rCT-1进行的急性治疗以非胰岛素依赖的方式降低了血糖，并增加了胰岛素刺激的肌肉AKT磷酸化。这些变化与脂肪酸氧化的刺激相关，AMPKalpha2（-/-）小鼠中没有这种作用。长期rCT-1治疗减少食物摄入，增加能量消耗并诱发白色脂肪组织重塑，其特征是上调参与脂解，脂肪酸氧化和线粒体生物发生的基因的上调，以及代表棕色脂肪表型的基因。此外，rCT-1可以减轻ob / ob和高脂饮食肥胖小鼠的体重，并改善其胰岛素抵抗。我们得出结论，CT-1是脂肪和葡萄糖代谢的主要调节剂，在治疗肥胖症和胰岛素抵抗方面具有潜在的应用前景。

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