• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell metabolism >Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase.
【24h】

Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase.

机译：脂滴扩展的磷脂酰胆碱合成是由CTP：磷酸胆碱胞苷转移酶的局部活化介导的。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Lipid droplets (LDs) are cellular storage organelles for neutral lipids that vary in size and abundance according to cellular needs. Physiological conditions that promote lipid storage rapidly and markedly increase LD volume and surface. How the need for surface phospholipids is sensed and balanced during this process is unknown. Here, we show that phosphatidylcholine (PC) acts as a surfactant to prevent LD coalescence, which otherwise yields large, lipolysis-resistant LDs and triglyceride (TG) accumulation. The need for additional PC to coat the enlarging surface during LD expansion is provided by the Kennedy pathway, which is activated by reversible targeting of the rate-limiting enzyme, CTP:phosphocholine cytidylyltransferase (CCT), to growing LD surfaces. The requirement, targeting, and activation of CCT to growing LDs were similar in cells of Drosophila and mice. Our results reveal a mechanism to maintain PC homeostasis at the expanding LD monolayer through targeted activation of a key PC synthesis enzyme.
机译：脂质滴（LDs）是中性脂质的细胞存储细胞器，中性脂质的大小和丰度根据细胞的需要而变化。迅速促进脂质存储并显着增加LD体积和表面的生理条件。在此过程中如何感测和平衡对表面磷脂的需求尚不清楚。在这里，我们表明磷脂酰胆碱（PC）作为表面活性剂来防止LD聚结，否则会产生大的抗脂解性LD和甘油三酸酯（TG）积累。肯尼迪途径提供了在LD扩张期间需要额外的PC来覆盖扩大的表面的途径，肯尼迪途径可通过将限速酶CTP：磷酸胆碱胞苷转移酶（CCT）可逆地靶向生长的LD表面来激活。在果蝇和小鼠的细胞中，对生长中的LDs的CCT的需求，靶向和激活是相似的。我们的结果揭示了通过关键PC合成酶的靶向活化来维持PC稳态在扩大的LD单层的机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号