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首页> 外文期刊>Cell metabolism >The arrestin domain-containing 3 protein regulates body mass and energy expenditure.
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The arrestin domain-containing 3 protein regulates body mass and energy expenditure.

机译：包含抑制蛋白域的3蛋白调节体重和能量消耗。

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摘要

A human genome-wide linkage scan for obesity identified a linkage peak on chromosome 5q13-15. Positional cloning revealed an association of a rare haplotype to high body-mass index (BMI) in males but not females. The risk locus contains a single gene, "arrestin domain-containing 3" (ARRDC3), an uncharacterized alpha-arrestin. Inactivating Arrdc3 in mice led to a striking resistance to obesity, with greater impact on male mice. Mice with decreased ARRDC3 levels were protected from obesity due to increased energy expenditure through increased activity levels and increased thermogenesis of both brown and white adipose tissues. ARRDC3 interacted directly with beta-adrenergic receptors, and loss of ARRDC3 increased the response to beta-adrenergic stimulation in isolated adipose tissue. These results demonstrate that ARRDC3 is a gender-sensitive regulator of obesity and energy expenditure and reveal a surprising diversity for arrestin family protein functions.
机译：肥胖的人类全基因组连锁扫描确定了染色体5q13-15上的连锁峰。位置克隆揭示了男性而非女性中罕见的单倍型与高体重指数（BMI）的关联。风险位点包含单个基因“含arrestin域的3”（ARRDC3），即未表征的α-arrestin。灭活Arrdc3的小鼠对肥胖具有显着的抵抗力，对雄性小鼠的影响更大。 ARRDC3水平降低的小鼠可通过增加活动水平和增加棕色和白色脂肪组织的生热作用来增加能量消耗，从而避免肥胖。 ARRDC3与β-肾上腺素受体直接相互作用，并且ARRDC3的丢失增加了对孤立脂肪组织中对β-肾上腺素刺激的反应。这些结果表明ARRDC3是肥胖和能量消耗的性别敏感调节剂，并揭示了抑制蛋白家族蛋白功能的惊人多样性。

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