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首页> 外文期刊>Cell metabolism >Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase.
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Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase.

机译：肌醇多磷酸多激酶介导的mTOR氨基酸信号传递。

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摘要

mTOR complex 1 (mTORC1; mammalian target of rapamycin [mTOR] in complex with raptor) is a key regulator of protein synthesis and cell growth in response to nutrient amino acids. Here we report that inositol polyphosphate multikinase (IPMK), which possesses both inositol phosphate kinase and lipid kinase activities, regulates amino acid signaling to mTORC1. This regulation is independent of IPMK's catalytic function, instead reflecting its binding with mTOR and raptor, which maintains the mTOR-raptor association. Thus, IPMK appears to be a physiologic mTOR cofactor, serving as a determinant of mTORC1 stability and amino acid-induced mTOR signaling. Substances that block IPMK-mTORC1 binding may afford therapeutic benefit in nutrient amino acid-regulated conditions such as obesity and diabetes.
机译：mTOR复合物1（mTORC1;雷帕霉素的哺乳动物靶标[mTOR]与猛禽复合物）是响应营养氨基酸而蛋白质合成和细胞生长的关键调节剂。在这里，我们报告肌醇多磷酸多激酶（IPMK）具有肌醇磷酸激酶和脂质激酶的活性，调节向mTORC1的氨基酸信号传导。该调节独立于IPMK的催化功能，而是反映了其与mTOR和猛禽的结合，从而保持了mTOR-猛禽的缔合。因此，IPMK似乎是一种生理性mTOR辅助因子，可作为mTORC1稳定性和氨基酸诱导的mTOR信号传导的决定因素。阻断IPMK-mTORC1结合的物质可能在营养性氨基酸调节的疾病（例如肥胖症和糖尿病）中提供治疗益处。

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