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首页> 外文期刊>Nutrition Research >Plant stanol esters in low-fat yogurt reduces total and low-density lipoprotein cholesterol and low-density lipoprotein oxidation in normocholesterolemic and mildly hypercholesterolemic subjects.
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Plant stanol esters in low-fat yogurt reduces total and low-density lipoprotein cholesterol and low-density lipoprotein oxidation in normocholesterolemic and mildly hypercholesterolemic subjects.

机译:低脂酸奶中的植物甾烷醇酯可降低正常胆固醇血症和轻度高胆固醇血症受试者的总胆固醇和低密度脂蛋白胆固醇,以及低密度脂蛋白氧化。

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摘要

We examined the effects of plant stanol ester contained in low-fat yogurt on serum lipids and low-density lipoprotein (LDL) oxidation in Korean young adults with normocholesterolemia and mild hypercholesterolemia. After screening tests (fasting total cholesterol, 174 to 251 mg/dL; and fasting triacylglycerols, <266 mg/dL), 51 subjects (28.7+or-0.7 years, 22.6+or-0.4 kg/m2) were included in the study and randomly assigned to a group receiving yogurt with either a plant stanol ester or a placebo. Four weeks' intake of plant stanol (2 g/d) as its fatty acid ester lowered total and LDL cholesterol levels by almost 6% and 10%, respectively, without affecting high-density lipoprotein cholesterol and triacylglycerol concentrations. Plasma oxidized LDL was also reduced by 5.4% in the test group. Serum beta -carotene and retinol were unchanged in both groups; however, lipid-corrected serum alpha -tocopherol was significantly increased in the test group (P<.05) We conclude that plant stanol ester contained in low-fat yogurt may be effective in reducing total and LDL cholesterol and oxidized LDL level in a habitual diet without restriction of fat and cholesterol intake. Foods containing plant sterols or stanols might be a useful tool for normocholesterolemic and mildly hypercholesterolemic individuals to prevent more severe hypercholesterolemia and cardiovascular disease..
机译:我们检查了低脂酸奶中所含植物甾烷醇酯对高胆固醇血症和轻度高胆固醇血症的韩国年轻人血清脂质和低密度脂蛋白(LDL)氧化的影响。筛选测试后(空腹总胆固醇174至251 mg / dL;空腹三酰甘油<266 mg / dL),该研究纳入了51名受试者(28.7岁或0.7岁以上,22.6岁或0.4 kg / m 2)并随机分配给接受酸奶和植物甾烷醇酯或安慰剂的人群。摄入植物甾烷醇(2克/天)作为其脂肪酸酯的四个星期,分别将总胆固醇和LDL胆固醇的水平降低了近6%和10%,而不会影响高密度脂蛋白胆固醇和三酰甘油的浓度。在测试组中,血浆氧化的LDL也降低了5.4%。两组的血清β-胡萝卜素和视黄醇没有变化。然而,在测试组中,经脂质校正的血清α-生育酚显着增加(P <.05)。我们得出结论,低脂酸奶中所含的植物甾烷醇酯可能有效降低习惯中的总胆固醇和低密度脂蛋白胆固醇和氧化型低密度脂蛋白饮食中不限制脂肪和胆固醇的摄入。含植物固醇或甾烷醇的食物可能对正常胆固醇和轻度高胆固醇血症的人有用,可预防更严重的高胆固醇血症和心血管疾病。

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