Insulin degludec results in lower rates of nocturnal hypoglycaemia and fasting plasma glucose vs. insulin glargine: A meta-analysis of seven clinical trials

Russell-Jones D.; Gall M. -A.; Niemeyer M.; Diamant M.; Del Prato S.

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Insulin degludec results in lower rates of nocturnal hypoglycaemia and fasting plasma glucose vs. insulin glargine: A meta-analysis of seven clinical trials

机译：与甘精胰岛素相比，地德胰岛素能降低夜间低血糖发生率和空腹血糖：一项七项临床试验的荟萃分析

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Background and aims: Basal insulin analogues have a reduced risk of hypoglycaemia compared with NPH insulin, but hypoglycaemia still remains a major impediment to achieving recommended fasting plasma glucose (FPG) targets in patients with diabetes. Insulin degludec (IDeg) is a new basal insulin that forms soluble multihexamers after subcutaneous injection resulting in an ultra-long duration of action and stable glucose-lowering effect. The aim of this analysis was to compare the effect of IDeg on FPG and nocturnal confirmed hypoglycaemia as compared to insulin glargine (IGlar).

机译：背景和目的：与NPH胰岛素相比，基础胰岛素类似物的低血糖风险降低，但是低血糖仍然是实现糖尿病患者推荐空腹血糖（FPG）指标的主要障碍。地格胰岛素（IDeg）是一种新的基础胰岛素，在皮下注射后可形成可溶性多六聚体，因此作用时间超长且具有稳定的降糖作用。该分析的目的是与胰岛素甘精胰岛素（IGlar）相比，比较IDeg对FPG和夜间确诊的低血糖的影响。

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《Nutrition, metabolism, and cardiovascular diseases: NMCD》 |2015年第10期|共8页
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Russell-Jones D.; Gall M. -A.; Niemeyer M.; Diamant M.; Del Prato S.;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Meta-analysis; Diabetes; Hypoglycaemia; Insulin therapy; Fasting plasma glucose;

机译：荟萃分析;糖尿病;低血糖;胰岛素治疗;空腹血糖;

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1. Insulin degludec results in lower rates of nocturnal hypoglycaemia and fasting plasma glucose vs. insulin glargine: A meta-analysis of seven clinical trials [J] . Russell-Jones D., Gall M. -A., Niemeyer M., Nutrition, metabolism, and cardiovascular diseases: NMCD . 2015,第10期

机译：与甘精胰岛素相比，地德胰岛素能降低夜间低血糖发生率和空腹血糖：一项七项临床试验的荟萃分析
2. Elderly Patients with Diabetes Experience a Lower Rate of Nocturnal Hypoglycaemia with Insulin Degludec than with Insulin Glargine: A Meta-Analysis of Phase IIIa Trials [J] . Christopher Sorli, Mark Warren, David Oyer, Drugs & Aging . 2013,第12期

机译：老年糖尿病患者使用胰岛素Degludec的夜间低血糖发生率低于使用胰岛素甘草碱的夜间低血糖发生率：IIIa期试验的荟萃分析
3. Elderly patients with diabetes experience a lower rate of nocturnal hypoglycaemia with insulin degludec than with insulin glargine: A meta-analysis of phase iiia trials [J] . SorliC., WarrenM., OyerD., Drugs and aging . 2013,第12期

机译：胰岛素脱地格的老年糖尿病患者夜间低血糖发生率比甘精胰岛素低：iiia期临床试验的荟萃分析
4. Insulin Degludec, Insulin Glargine U300, and Other Novel Insulin Formulations [C] . American College of Veterinary Internal Medicine Forum Conference . 2018

机译：胰岛素Degludec，胰岛素甘氨酸U300等新型胰岛素配方
5. Low-level serum arsenic and its effect on insulin and the glucose /insulin ratio of non-diabetic fasting human subjects [D] . Bahar, Ali Ibrahim. 2006

机译：低糖血清砷及其对非糖尿病空腹人胰岛素和葡萄糖/胰岛素比率的影响
6. The co‐formulation of insulin degludec and insulin aspart lowers fasting plasma glucose and rates of confirmed and nocturnal hypoglycaemia independent of baseline glycated haemoglobin levels disease duration or body mass index: A pooled meta‐analysis of phase III studies in patients with type 2 diabetes [O] . Martin Haluzík, Greg Fulcher, Thomas R. Pieber, -1

机译：地格曲胰岛素和门冬胰岛素的共同配方可降低空腹血糖确诊和夜间低血糖发生率而与基线糖化血红蛋白水平疾病持续时间或体重指数无关：对2型患者进行的III期研究汇总荟萃分析糖尿病
7. Insulin degludec results in lower rates of nocturnal hypoglycaemia and fasting plasma glucose vs. insulin glargine: A meta-analysis of seven clinical trials [O] . Russell-Jones, D, Gall, M.-A., Niemeyer, M., 2015

机译：与甘精胰岛素相比，地德胰岛素能降低夜间低血糖和空腹血糖的发生率：一项七项临床试验的荟萃分析

Insulin degludec results in lower rates of nocturnal hypoglycaemia and fasting plasma glucose vs. insulin glargine: A meta-analysis of seven clinical trials

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