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首页> 外文期刊>Cell metabolism >Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet
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Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

机译：在不减少热量摄入的情况下限时喂养可以预防高脂饮食小鼠的代谢性疾病

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摘要

While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat frequently throughout day and night, disrupting the normal feeding cycle. To test whether obesity and metabolic diseases result from HFD or disruption of metabolic cycles, we subjected mice to either ad lib or time-restricted feeding (tRF) of a HFD for 8 hr per day. Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination. The tRF regimen improved CREB, mTOR, and AMPK pathway function and oscillations of the circadian clock and their target genes' expression. These changes in catabolic and anabolic pathways altered liver metabolome and improved nutrient utilization and energy expenditure. We demonstrate in mice that tRF regimen is a nonpharmacological strategy against obesity and associated diseases.
机译：尽管饮食引起的肥胖完全归因于脂肪热量摄入的增加，但随意喂养高脂饮食（HFD）的动物昼夜频繁进食，破坏了正常的喂养周期。为了测试肥胖和代谢性疾病是否由HFD或代谢循环中断引起，我们每天对小鼠进行HFD随意或限时喂养（tRF）8小时。在tRF下的小鼠从HFD摄入的卡路里与那些可以自由进入的小鼠消耗的卡路里相当，但可以预防肥胖，高胰岛素血症，肝脂肪变性和炎症，并改善了运动协调性。 tRF方案改善了CREB，mTOR和AMPK通路的功能以及昼夜节律及其靶基因表达的振荡。分解代谢和合成代谢途径的这些变化改变了肝脏的代谢组，提高了养分利用率和能量消耗。我们在小鼠中证明了tRF方案是针对肥胖症和相关疾病的非药理学策略。

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