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首页> 外文期刊>Cell metabolism >AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. Elegans
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AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. Elegans

机译：AMP激活的激酶将血清素能信号传导与谷氨酸释放相关，以调节线虫的摄食行为

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摘要

Serotonergic regulation of feeding behavior has been studied intensively, both for an understanding of the basic neurocircuitry of energy balance in various organisms and as a therapeutic target for human obesity. However, its underlying molecular mechanisms remain poorly understood. Here, we show that neural serotonin signaling in C. elegans modulates feeding behavior through inhibition of AMP-activated kinase (AMPK) in interneurons expressing the C. elegans counterpart of human SIM1, a transcription factor associated with obesity. In turn, glutamatergic signaling links these interneurons to pharyngeal neurons implicated in feeding behavior. We show that AMPK-mediated regulation of glutamatergic release is conserved in rat hippocampal neurons. These findings reveal cellular and molecular mediators of serotonergic signaling.
机译：为了了解各种生物体中能量平衡的基本神经回路以及作为人类肥胖症的治疗靶标，对饲喂行为的血清素能调节进行了深入研究。然而，其潜在的分子机制仍然知之甚少。在这里，我们显示线虫中的神经元血清素信号传导通过抑制表达人SIM1线虫对应物（与肥胖相关的线虫）的中间神经元中的AMP活化激酶（AMPK）来调节进食行为。反过来，谷氨酸能信号将这些中间神经元链接到与进食行为有关的咽神经元。我们显示，AMPK介导的谷氨酸能释放调节在大鼠海马神经元中是保守的。这些发现揭示了血清素能信号传导的细胞和分子介质。

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