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首页> 外文期刊>Cell metabolism >The NAD + precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
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The NAD + precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

机译：NAD +前体烟酰胺核糖苷可增强氧化代谢，并防止高脂饮食引起的肥胖

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摘要

As NAD + is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line with this premise, decreased activity of PARP-1 or CD38 - both NAD + consumers - increases NAD + bioavailability, resulting in SIRT1 activation and protection against metabolic disease. Here we evaluated whether similar effects could be achieved by increasing the supply of nicotinamide riboside (NR), a recently described natural NAD + precursor with the ability to increase NAD + levels, Sir2-dependent gene silencing, and replicative life span in yeast. We show that NR supplementation in mammalian cells and mouse tissues increases NAD + levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities. Consequently, our results indicate that the natural vitamin NR could be used as a nutritional supplement to ameliorate metabolic and age-related disorders characterized by defective mitochondrial function.
机译：由于NAD +是Sirtuin酶的限速共底物，其调节作用正逐渐成为调节Sirtuin功能和氧化代谢的重要工具。根据这一前提，降低PARP-1或CD38的活性-NAD +消费者-增加NAD +生物利用度，从而导致SIRT1活化并抵抗代谢性疾病。在这里，我们评估了是否可以通过增加烟酰胺核糖（NR）的供应来达到类似的效果，这是一种最近描述的天然NAD +前体，具有增加NAD +水平，Sir2依赖性基因沉默和酵母复制寿命的能力。我们显示，在哺乳动物细胞和小鼠组织中补充NR会增加NAD +水平并激活SIRT1和SIRT3，最终导致氧化代谢增强，并防止高脂饮食引起的代谢异常。因此，我们的结果表明，天然维生素NR可用作营养补充剂，以改善以线粒体功能缺陷为特征的代谢和与年龄有关的疾病。

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