Direct and indirect gene regulation by a life-extending foxo protein in C. elegans: Roles for GATA factors and lipid gene regulators

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Direct and indirect gene regulation by a life-extending foxo protein in C. elegans: Roles for GATA factors and lipid gene regulators

机译：秀丽隐杆线虫中一种延长生命的狐狸蛋白的直接和间接基因调控：GATA因子和脂质基因调控剂的作用

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In long-lived C. elegans insulin/IGF-1 pathway mutants, the life-extending FOXO transcription factor DAF-16 is present throughout the animal, but we find that its activity in a single tissue can delay the aging of other tissues and extend the animal's life span. To better understand the topography of DAF-16 action among the tissues, we analyzed a collection of DAF-16-regulated genes. DAF-16 regulated most of these genes in a cell-autonomous fashion, often using tissue-specific GATA factors to direct their expression to specific tissues. DAF-16 could also act cell nonautonomously to influence gene expression. DAF-16 affected gene expression in other cells, at least in part, via the lipid-gene regulator MDT-15. DAF-16, and probably MDT-15, could act cell nonautonomously in the endoderm to ameliorate the paralysis caused by expressing Alzheimer's Aβ protein in muscles. These findings suggest that MDT-15-dependent intercellular signals, possibly lipid signals, can help to coordinate tissue physiology, enhance proteostasis, and extend life in response to DAF-16/FOXO activity.

机译：在长寿命的秀丽线虫胰岛素/ IGF-1途径突变体中，延长寿命的FOXO转录因子DAF-16存在于整个动物中，但是我们发现其在单个组织中的活性可以延迟其他组织的衰老并延长动物的寿命。为了更好地了解组织中DAF-16作用的形貌，我们分析了DAF-16调控基因的集合。 DAF-16通常以组织特异性GATA因子将其表达定向到特定组织，从而以细胞自主方式调节大多数这些基因。 DAF-16还可以非自主地作用于细胞以影响基因表达。 DAF-16至少部分通过脂质基因调节剂MDT-15影响了其他细胞中的基因表达。 DAF-16以及可能的MDT-15可以在内胚层中非自主地发挥作用，以缓解因在肌肉中表达阿尔茨海默氏Aβ蛋白而引起的瘫痪。这些发现表明，响应DAF-16 / FOXO活性，依赖MDT-15的细胞间信号（可能是脂质信号）可以帮助协调组织生理，增强蛋白稳态，并延长寿命。

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《Cell metabolism》 |2013年第1期|共16页
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中图分类内分泌腺疾病及代谢病;
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1. Direct and indirect gene regulation by a life-extending foxo protein in C. elegans: Roles for GATA factors and lipid gene regulators [J] . Cell metabolism . 2013,第1期

机译：秀丽隐杆线虫中一种延长生命的狐狸蛋白的直接和间接基因调控：GATA因子和脂质基因调控剂的作用
2. Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6 [J] . Wan-Ju Liu, John S Reece-Hoyes, Albertha JM Walhout, BMC Developmental Biology . 2014,第1期

机译：多种转录因子直接调控线虫胚胎和幼虫腹侧皮下细胞中Hox基因lin-39的表达，包括皮下缘份调节剂LIN-26和ELT-6
3. Indirect role of microRNAs and transcription factors in the regulation of important cancer genes: A network biology approach [J] . Ahmadi M., Jafari R., Marashi S. A., Cellular and molecular biology . 2015,第6期

机译：microRNA和转录因子在重要癌症基因调控中的间接作用：一种网络生物学方法
4. Regulation of Genes Involved in Lipid Homeostasis and the Pathogenesis of Atherosclerosis: The Role of Promoters, Enhancers, Hormone Nuclear Receptors and Auxiliary Factors in Apolipoprotein Gene Regulation [C] . Vassilis Zannis, Eleoi Zanni, Dimitris Kardassis NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：调节患有脂质稳态的基因和动脉粥样硬化的发病机制：启动子，增强剂，激素核受体和载脂蛋白基因调控中的辅助因子的作用
5. Regulation of C. elegans developmental timing by the GATA transcription factor elt-1. [D] . Cohen, Max Louis. 2013

机译：GATA转录因子elt-1对秀丽隐杆线虫发育时间的调节。
6. Direct and Indirect Gene Regulation by a Life-Extending FOXO Protein in C. elegans: Roles for GATA Factors and Lipid Gene Regulators [O] . Peichuan Zhang, Meredith Judy, Seung-Jae Lee, -1

机译：直接和线虫的生命延长FOXO蛋白间接基因调控：角色GaTa因子和脂质调节基因
7. Direct and Indirect Gene Regulation by a Life-Extending FOXO Protein in C. elegans: Roles for GATA Factors and Lipid Gene Regulators [O] . Zhang Peichuan, Judy Meredith, Lee Seung-Jae, 2013

机译：延长寿命的FOXO线虫中的直接和间接基因调控线虫：GATA因子和脂质基因调节剂的作用
8. Characterization of Two C. Elegans Homologuses of Oncogenic Inhibitor of Apoptosis Proteins (IAPs) and Identification of Interacting Genes. [R] . Fraser, A. G., Ahringer, J. 2002

机译：细胞凋亡蛋白（Iaps）致癌抑制剂两种线虫同系物的表征及相互作用基因的鉴定。

Direct and indirect gene regulation by a life-extending foxo protein in C. elegans: Roles for GATA factors and lipid gene regulators

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